HMM of Nav1.7 WT and F1449V (Gurkiewicz et al. 2011)


Gurkiewicz M, Korngreen A, Waxman SG, Lampert A. (2011). Kinetic modeling of Nav1.7 provides insight into erythromelalgia-associated F1449V mutation. Journal of neurophysiology. 105 [PubMed]

See more from authors: Gurkiewicz M · Korngreen A · Waxman SG · Lampert A

References and models cited by this paper

Akaike H. (1974). A new look at the statistical model identification IEEE Trans Appl Comp. 19

Armstrong CM. (2006). Na channel inactivation from open and closed states. Proceedings of the National Academy of Sciences of the United States of America. 103 [PubMed]

Armstrong CM, Bezanilla F. (1977). Inactivation of the sodium channel. II. Gating current experiments. The Journal of general physiology. 70 [PubMed]

Armstrong CM, Bezanilla F, Rojas E. (1973). Destruction of sodium conductance inactivation in squid axons perfused with pronase. The Journal of general physiology. 62 [PubMed]

Armstrong CM, Hille B. (1998). Voltage-gated ion channels and electrical excitability. Neuron. 20 [PubMed]

Baranauskas G, Martina M. (2006). Sodium currents activate without a Hodgkin-and-Huxley-type delay in central mammalian neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Bean BP. (2005). The molecular machinery of resurgent sodium current revealed. Neuron. 45 [PubMed]

Bezanilla F, Armstrong CM. (1974). Gating currents of the sodium channels: three ways to block them. Science (New York, N.Y.). 183 [PubMed]

Blair NT, Bean BP. (2002). Roles of tetrodotoxin (TTX)-sensitive Na+ current, TTX-resistant Na+ current, and Ca2+ current in the action potentials of nociceptive sensory neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22 [PubMed]

Catterall WA. (2000). From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. Neuron. 26 [PubMed]

Cestèle S et al. (2006). Structure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin. The Journal of biological chemistry. 281 [PubMed]

Chanda B, Asamoah OK, Bezanilla F. (2004). Coupling interactions between voltage sensors of the sodium channel as revealed by site-specific measurements. The Journal of general physiology. 123 [PubMed]

Chanda B, Bezanilla F. (2002). Tracking voltage-dependent conformational changes in skeletal muscle sodium channel during activation. The Journal of general physiology. 120 [PubMed]

Clancy CE, Kass RS. (2004). Theoretical investigation of the neuronal Na+ channel SCN1A: abnormal gating and epilepsy. Biophysical journal. 86 [PubMed]

Clancy CE, Rudy Y. (2002). Na(+) channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism. Circulation. 105 [PubMed]

Colquhoun D, Dowsland KA, Beato M, Plested AJ. (2004). How to impose microscopic reversibility in complex reaction mechanisms. Biophysical journal. 86 [PubMed]

Cummins TR, Howe JR, Waxman SG. (1998). Slow closed-state inactivation: a novel mechanism underlying ramp currents in cells expressing the hNE/PN1 sodium channel. The Journal of neuroscience : the official journal of the Society for Neuroscience. 18 [PubMed]

Cummins TR, Rush AM, Estacion M, Dib-Hajj SD, Waxman SG. (2009). Voltage-clamp and current-clamp recordings from mammalian DRG neurons. Nature protocols. 4 [PubMed]

Cummins TR et al. (1993). Functional consequences of a Na+ channel mutation causing hyperkalemic periodic paralysis. Neuron. 10 [PubMed]

Dib-Hajj SD, Cummins TR, Black JA, Waxman SG. (2010). Sodium channels in normal and pathological pain. Annual review of neuroscience. 33 [PubMed]

Dib-Hajj SD et al. (2005). Gain-of-function mutation in Nav1.7 in familial erythromelalgia induces bursting of sensory neurons. Brain : a journal of neurology. 128 [PubMed]

Doyle DA et al. (1998). The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science (New York, N.Y.). 280 [PubMed]

Faber GM, Rudy Y. (2000). Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study. Biophysical journal. 78 [PubMed]

Goldman L, Schauf CL. (1972). Inactivation of the sodium current in Myxicola giant axons. Evidence for coupling to the activation process. The Journal of general physiology. 59 [PubMed]

Gonoi T, Hille B. (1987). Gating of Na channels. Inactivation modifiers discriminate among models. The Journal of general physiology. 89 [PubMed]

Gurkiewicz M, Korngreen A. (2007). A numerical approach to ion channel modelling using whole-cell voltage-clamp recordings and a genetic algorithm. PLoS computational biology. 3 [PubMed]

HODGKIN AL, HUXLEY AF, KATZ B. (1952). Measurement of current-voltage relations in the membrane of the giant axon of Loligo. The Journal of physiology. 116 [PubMed]

Han C et al. (2009). Early- and late-onset inherited erythromelalgia: genotype-phenotype correlation. Brain : a journal of neurology. 132 [PubMed]

Harty TP et al. (2006). Na(V)1.7 mutant A863P in erythromelalgia: effects of altered activation and steady-state inactivation on excitability of nociceptive dorsal root ganglion neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Horn R. (1987). Statistical methods for model discrimination. Applications to gating kinetics and permeation of the acetylcholine receptor channel. Biophysical journal. 51 [PubMed]

Huth T, Schmidtmayer J, Alzheimer C, Hansen UP. (2008). Four-mode gating model of fast inactivation of sodium channel Nav1.2a. Pflugers Archiv : European journal of physiology. 457 [PubMed]

Jiang Y et al. (2002). The open pore conformation of potassium channels. Nature. 417 [PubMed]

Keren N, Bar-Yehuda D, Korngreen A. (2009). Experimentally guided modelling of dendritic excitability in rat neocortical pyramidal neurones. The Journal of physiology. 587 [PubMed]

Korngreen A, Sakmann B. (2000). Voltage-gated K+ channels in layer 5 neocortical pyramidal neurones from young rats: subtypes and gradients. The Journal of physiology. 525 Pt 3 [PubMed]

Lampert A et al. (2008). A pore-blocking hydrophobic motif at the cytoplasmic aperture of the closed-state Nav1.7 channel is disrupted by the erythromelalgia-associated F1449V mutation. The Journal of biological chemistry. 283 [PubMed]

Lampert A, O'Reilly AO, Reeh P, Leffler A. (2010). Sodium channelopathies and pain. Pflugers Archiv : European journal of physiology. 460 [PubMed]

Lipkind GM, Fozzard HA. (2008). Voltage-gated Na channel selectivity: the role of the conserved domain III lysine residue. The Journal of general physiology. 131 [PubMed]

Mainen ZF, Joerges J, Huguenard JR, Sejnowski TJ. (1995). A model of spike initiation in neocortical pyramidal neurons. Neuron. 15 [PubMed]

Menon V, Spruston N, Kath WL. (2009). A state-mutating genetic algorithm to design ion-channel models. Proceedings of the National Academy of Sciences of the United States of America. 106 [PubMed]

Milescu LS, Yamanishi T, Ptak K, Mogri MZ, Smith JC. (2008). Real-time kinetic modeling of voltage-gated ion channels using dynamic clamp. Biophysical journal. 95 [PubMed]

Mitchell M. (1996). An Introduction to Genetic Algorithms.

O'Reilly AO et al. (2006). Modelling insecticide-binding sites in the voltage-gated sodium channel. The Biochemical journal. 396 [PubMed]

Patlak J. (1991). Molecular kinetics of voltage-dependent Na+ channels. Physiological reviews. 71 [PubMed]

Petitprez S et al. (2008). Analyses of a novel SCN5A mutation (C1850S): conduction vs. repolarization disorder hypotheses in the Brugada syndrome. Cardiovascular research. 78 [PubMed]

Press WH. (2002). Numerical recipes in C++ : the art of scientific computing.

Raman IM, Bean BP. (1997). Resurgent sodium current and action potential formation in dissociated cerebellar Purkinje neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 17 [PubMed]

Renganathan M, Cummins TR, Waxman SG. (2001). Contribution of Na(v)1.8 sodium channels to action potential electrogenesis in DRG neurons. Journal of neurophysiology. 86 [PubMed]

Ruan Y et al. (2010). Trafficking defects and gating abnormalities of a novel SCN5A mutation question gene-specific therapy in long QT syndrome type 3. Circulation research. 106 [PubMed]

Rudy B. (1978). Slow inactivation of the sodium conductance in squid giant axons. Pronase resistance. The Journal of physiology. 283 [PubMed]

Rush AM et al. (2006). A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons. Proceedings of the National Academy of Sciences of the United States of America. 103 [PubMed]

Scheib H et al. (2006). Modeling the pore structure of voltage-gated sodium channels in closed, open, and fast-inactivated conformation reveals details of site 1 toxin and local anesthetic binding. Journal of molecular modeling. 12 [PubMed]

Sheets PL, Jackson JO, Waxman SG, Dib-Hajj SD, Cummins TR. (2007). A Nav1.7 channel mutation associated with hereditary erythromelalgia contributes to neuronal hyperexcitability and displays reduced lidocaine sensitivity. The Journal of physiology. 581 [PubMed]

Tao X, Lee A, Limapichat W, Dougherty DA, MacKinnon R. (2010). A gating charge transfer center in voltage sensors. Science (New York, N.Y.). 328 [PubMed]

Thomas EA, Reid CA, Petrou S. (2010). Mossy fiber sprouting interacts with sodium channel mutations to increase dentate gyrus excitability. Epilepsia. 51 [PubMed]

Thomas EA, Xu R, Petrou S. (2007). Computational analysis of the R85C and R85H epilepsy mutations in Na+ channel beta1 subunits. Neuroscience. 147 [PubMed]

Tikhonov DB, Zhorov BS. (2005). Modeling P-loops domain of sodium channel: homology with potassium channels and interaction with ligands. Biophysical journal. 88 [PubMed]

Uysal S et al. (2009). Crystal structure of full-length KcsA in its closed conformation. Proceedings of the National Academy of Sciences of the United States of America. 106 [PubMed]

Vandenberg CA, Bezanilla F. (1991). A sodium channel gating model based on single channel, macroscopic ionic, and gating currents in the squid giant axon. Biophysical journal. 60 [PubMed]

Vecchietti S et al. (2007). In silico assessment of Y1795C and Y1795H SCN5A mutations: implication for inherited arrhythmogenic syndromes. American journal of physiology. Heart and circulatory physiology. 292 [PubMed]

Yang Y et al. (2004). Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia. Journal of medical genetics. 41 [PubMed]

ten Tusscher KH, Panfilov AV. (2006). Alternans and spiral breakup in a human ventricular tissue model. American journal of physiology. Heart and circulatory physiology. 291 [PubMed]

References and models that cite this paper

Feng B, Zhu Y, La JH, Wills ZP, Gebhart GF. (2015). Experimental and computational evidence for an essential role of NaV1.6 in spike initiation at stretch-sensitive colorectal afferent endings. Journal of neurophysiology. 113 [PubMed]

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.