Mechanisms of magnetic stimulation of central nervous system neurons (Pashut et al. 2011)

Transcranial magnetic stimulation (TMS) is a widely applied tool for probing cognitive function in humans and is one of the best tools for clinical treatments and interfering with cognitive tasks. Surprisingly, while TMS has been commercially available for decades, the cellular mechanisms underlying magnetic stimulation remain unclear. Here we investigate these mechanisms using compartmental modeling. We generated a numerical scheme allowing simulation of the physiological response to magnetic stimulation of neurons with arbitrary morphologies and active properties. Computational experiments using this scheme suggested that TMS affects neurons in the central nervous system (CNS) primarily by somatic stimulation.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Squid axon

Model Concept(s): Action Potential Initiation; Magnetic stimulation

Simulation Environment: NEURON; MATLAB

Implementer(s): Korngreen, Alon [alon.korngreen at]; Pashut, Tamar [tamar.pashut at]


Pashut T et al. (2011). Mechanisms of magnetic stimulation of central nervous system neurons. PLoS computational biology. 7 [PubMed]

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