This is a multi-compartmental, stochastic version of the Kim et al. 2010 paper. There are a few additional reactions, and some of the rate constants have been updated. It addresses the role of molecule anchoring in PKA dependent hippocampal LTP.
Model Type: Synapse
Cell Type(s): Hippocampus CA1 pyramidal GLU cell
Receptors: Dopaminergic Receptor
Transmitters: Dopamine
Model Concept(s): Long-term Synaptic Plasticity; Signaling pathways
Simulation Environment: NeuroRD
Implementer(s): Blackwell, Avrama [avrama at gmu.edu]
References:
Kim M et al. (2011). Colocalization of protein kinase A with adenylyl cyclase enhances protein kinase A activity during induction of long-lasting long-term-potentiation. PLoS computational biology. 7 [PubMed]