Dipole Localization Kit (Mechler & Victor, 2012)

We localize a single neuron from the spatial sample of its EAP amplitudes recorded with a multisite probe (with 6 or more independent measurement sites or channels, e.g., a silicon polytrode, a stepped tetrode, etc.) This is an inverse problem and we solve it by fitting a model to the EAPs that consists of a volume conductor model of the neural tissue (known), a realistic model of the probe (known), and a single dipole current source of the model neuron (unknown). The dipole is free to change position, size, and orientation (a total of 6 parameters) at each moment during the action potential.

Model Type: Extracellular

Model Concept(s): Methods

Simulation Environment: MATLAB

Implementer(s): Mechler, Ferenc [fmechler at med.cornell.edu]


Mechler F, Victor JD. (2012). Dipole characterization of single neurons from their extracellular action potentials. Journal of computational neuroscience. 32 [PubMed]

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