We localize a single neuron from the spatial sample of its EAP amplitudes recorded with a multisite probe (with 6 or more independent measurement sites or channels, e.g., a silicon polytrode, a stepped tetrode, etc.) This is an inverse problem and we solve it by fitting a model to the EAPs that consists of a volume conductor model of the neural tissue (known), a realistic model of the probe (known), and a single dipole current source of the model neuron (unknown). The dipole is free to change position, size, and orientation (a total of 6 parameters) at each moment during the action potential.
Model Type: Extracellular
Model Concept(s): Methods
Simulation Environment: MATLAB
Implementer(s): Mechler, Ferenc [fmechler at med.cornell.edu]
References:
Mechler F, Victor JD. (2012). Dipole characterization of single neurons from their extracellular action potentials. Journal of computational neuroscience. 32 [PubMed]