"Synaptic plasticity leads to long-term changes in excitability, whereas cellular homeostasis maintains excitability. Both these processes involve interactions between molecular events, electrical events, and network activity. Here I explore these intersections with a multilevel model that embeds molecular events following synaptic calcium influx into a multicompartmental electrical model of a CA1 hippocampal neuron. ..."
Cell Type(s): Hippocampus CA1 pyramidal GLU cell
Simulation Environment: GENESIS
Implementer(s): Bhalla, Upinder S [bhalla at ncbs.res.in]
Bhalla US. (2011). Multiscale interactions between chemical and electric signaling in LTP induction, LTP reversal and dendritic excitability. Neural networks : the official journal of the International Neural Network Society. 24 [PubMed]