The model is a point neuron model with ionic currents from Rothman & Mannis (2003) and with an update of the low threshold potassium current (IKLT) measured in-vitro by Mathews & Jercog et al (2010). This model in conjunction with the synaptic input models presented here has been used to gain insight into mechanisms that account for experimentally observed asymmetries in ITD tuning (Brand et al, 2002). Asymmetry and displacement of the ITD response function is achieved in the model by the interplay between asymmetry of the excitatory inputs arriving from the two sides and the precise voltage dependent activation of IKLT. In Jercog et al (2010) we propose two different mathematical ways, physiologically plausible scenarios, of generating the asymmetry in the bilateral synaptic input events. Here, we present two models for simulating the stochastic synaptic input trains.
Model Type: Axon
Cell Type(s): Medial Superior Olive (MSO) cell
Simulation Environment: C or C++ program
Implementer(s): Jercog, Pablo [pjercog at gmail.com]
Jercog PE, Svirskis G, Kotak VC, Sanes DH, Rinzel J. (2010). Asymmetric excitatory synaptic dynamics underlie interaural time difference processing in the auditory system. PLoS biology. 8 [PubMed]