ClC-2 channels regulate neuronal excitability, not intracellular Cl- levels (Ratte & Prescott 2011)


RattePrescott2011/ClC2-IClamp-Prescott.ode

betap 15
betay 0
bicarb 1
cap 2
clo 120
F 96485
gadapt 3
gammap -14
gammay 5
gclc 0
gexc_avg 0.4
ginh_avg 1
gk 20
gkcc2 0.7
gl 1
gna 20
I_stim1 0
idc 0
phi 0.25
R 8.3
ra 0.0063
scale_exc 0.1
scale_inh 0.1
shape 3
t_r_offinh 100000
t_run 100000
t_run_exc 100000
t_start 0
tau_exc 2
tau_inh 10
taup 300
tauy 100
Tem 310
tst_oninh 0
tstart_exc 0
v1 -1.2
v2 18
v3 -9
v4 10
vexc 0
vk -90
vl -70
vna 45

RattePrescott2011/ClC2-VClamp-Prescott.ode

betap 15
bicarb 1
cap 2
clo 120
F 96485
gammap -14
gclc 0
ginh_avg 1
gk 20
gkcc2 0.7
gl 1
gna 20
phi 0.25
pip_cl 4
R 8.3
ra 0.0063
scale_inh 0
shape 3
tau_inh 10
tau_pip 1000
taup 300
tb 2000
tc 4000
Tem 310
tr_offinh 4000
tst_oninh 0
v1 -1.2
v2 18
v3 -9
v4 10
va -70
vb 130
vc -150
vk -90
vl -70
vna 45
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