Effects of the membrane AHP on the Lateral Superior Olive (LSO) (Zhou & Colburn 2010)

This simulation study investigated how membrane afterhyperpolarization (AHP) influences spiking activity of neurons in the Lateral Superior Olive (LSO). The model incorporates a general integrate-and-fire spiking mechanism with a first-order adaptation channel. Simulations focus on differentiating the effects of GAHP, tauAHP, and input strength on (1) spike interval statistics, such as negative serial correlation and chopper onset, and (2) neural sensitivity to interaural level difference (ILD) of LSO neurons. The model simulated electrophysiological data collected in cat LSO (Tsuchitani and Johnson, 1985).

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Auditory brainstem

Cell Type(s): Lateral Superior Olive (LSO) cell; Abstract integrate-and-fire leaky neuron

Currents: I_AHP

Receptors: GabaA; Glutamate

Model Concept(s): Action Potential Initiation; Simplified Models; Spike Frequency Adaptation; Depolarization block; Audition

Simulation Environment: NEURON; MATLAB

Implementer(s): Zhou, Yi [yizhou at bu.edu]


Zhou Y, Colburn HS. (2010). A modeling study of the effects of membrane afterhyperpolarization on spike interval statistics and on ILD encoding in the lateral superior olive. Journal of neurophysiology. 103 [PubMed]

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