Synchrony by synapse location (McTavish et al. 2012)

This model considers synchrony between mitral cells induced via shared granule cell interneurons while taking into account the spatial constraints of the system. In particular, since inhibitory inputs decay passively along the lateral dendrites, this model demonstrates that an optimal arrangement of the inhibitory synapses will be near the cell bodies of the relevant mitral cells.

Model Type: Realistic Network; Neuron or other electrically excitable cell

Region(s) or Organism(s): Olfactory bulb

Cell Type(s): Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron granule MC GABA cell

Currents: I Na,t; I A; I K

Receptors: GabaB; AMPA; NMDA

Model Concept(s): Synchronization; Olfaction

Simulation Environment: NEURON

Implementer(s): McTavish, Thomas S [thomas.mctavish at yale.edu]

References:

McTavish TS, Migliore M, Shepherd GM, Hines ML. (2012). Mitral cell spike synchrony modulated by dendrodendritic synapse location. Frontiers in computational neuroscience. 6 [PubMed]