CA1 pyramidal neuron dendritic spine with plasticity (O`Donnell et al. 2011)

Biophysical model of a dendritic spine and adjacent dendrite with synapse. Model parameters adjusted to fit CA3-CA1 Shaffer collateral synapse data from literature. Model includes both electrical and Ca2+ dynamics, including AMPARs, NMDARs, 4 types of CaV channel, and leak conductance. Spine and synapse are plastic according to Ca2+ dependent rule. The aim of the model is to explore the effects of dendritic spine structural plasticity on the rules of synaptic plasticity.

Model Type: Synapse; Dendrite

Cell Type(s): Hippocampus CA1 pyramidal GLU cell

Receptors: AMPA; NMDA

Genes: Cav3.1 CACNA1G; Cav1.3 CACNA1D; Cav1.2 CACNA1C; Cav2.1 CACNA1A

Transmitters: Glutamate

Model Concept(s): Synaptic Plasticity; Calcium dynamics

Simulation Environment: MATLAB

Implementer(s): O`Donnell, Cian [cian AT]


O'Donnell C, Nolan MF, van Rossum MC. (2011). Dendritic spine dynamics regulate the long-term stability of synaptic plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31 [PubMed]

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.