Biophysical model of a dendritic spine and adjacent dendrite with synapse. Model parameters adjusted to fit CA3-CA1 Shaffer collateral synapse data from literature. Model includes both electrical and Ca2+ dynamics, including AMPARs, NMDARs, 4 types of CaV channel, and leak conductance. Spine and synapse are plastic according to Ca2+ dependent rule. The aim of the model is to explore the effects of dendritic spine structural plasticity on the rules of synaptic plasticity.
Cell Type(s): Hippocampus CA1 pyramidal GLU cell
Simulation Environment: MATLAB
Implementer(s): O`Donnell, Cian [cian AT salk.edu]
O'Donnell C, Nolan MF, van Rossum MC. (2011). Dendritic spine dynamics regulate the long-term stability of synaptic plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31 [PubMed]