Hypocretin and Locus Coeruleus model neurons (Carter et al 2012)

Conductance based model of the hypocretin neurons (HCRT) and another one of the Locus Coeruleus one (LC). The HCRT drive the LCs via the HCRT receptor on the LCs. The LCs lead to the awakening of the mice if the number of spikes raises over 10 spikes in 10 seconds window.

Model Type: Axon; Channel/Receptor

Cell Type(s): Locus Coeruleus neuron

Currents: I Na,t; I T low threshold; I A; I K; I K,Ca; I Calcium

Simulation Environment: C or C++ program

Implementer(s): Huerta, Ramon [rhuerta at ucsd.edu]


Carter ME et al. (2012). Mechanism for Hypocretin-mediated sleep-to-wake transitions Proceedings of the National Academy of Sciences of the United States of America. 109 [PubMed]

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