Conductance based model of the hypocretin neurons (HCRT) and another one of the Locus Coeruleus one (LC). The HCRT drive the LCs via the HCRT receptor on the LCs. The LCs lead to the awakening of the mice if the number of spikes raises over 10 spikes in 10 seconds window.
Cell Type(s): Locus Coeruleus neuron
Simulation Environment: C or C++ program
Implementer(s): Huerta, Ramon [rhuerta at ucsd.edu]
Carter ME et al. (2012). Mechanism for Hypocretin-mediated sleep-to-wake transitions Proceedings of the National Academy of Sciences of the United States of America. 109 [PubMed]