" ... Although the BCM-like plasticity framework has been a useful formulation to understand synaptic plasticity and metaplasticity, a mechanism for the activity-dependent regulation of this modification threshold has remained an open question. In this simulation study based on CA1 pyramidal cells, we use a modification of the calcium-dependent hypothesis proposed elsewhere and show that a change in the hyperpolarization-activated, nonspecific-cation h current is capable of shifting the modification threshold. ..."
Region(s) or Organism(s): Hippocampus
Cell Type(s): Hippocampus CA1 pyramidal GLU cell
Simulation Environment: NEURON
Implementer(s): Narayanan, Rishikesh [rishi at iisc.ac.in]
Narayanan R, Johnston D. (2010). The h current is a candidate mechanism for regulating the sliding modification threshold in a BCM-like synaptic learning rule. Journal of neurophysiology. 104 [PubMed]