Circadian clock model in mammals (PK/PD model) (Kim & Forger 2013)

A systems pharmacology model of the mammalian circadian clock including PF-670462 (CK1d/e inhibitor).

Model Type: Molecular Network

Cell Type(s): Suprachiasmatic nucleus (SCN) neuron

Model Concept(s): Therapeutics; Phase Response Curves; Circadian Rhythms

Simulation Environment: Mathematica

Implementer(s): Kim, Jae Kyoung [kimjack0 at]


Wood D et al. (2013). Modeling and validating chronic pharmacological manipulation of circadian rhythms CPT: Pharmacometrics & Systems Pharmacology. 2(7)

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.