This model is constructed based on properties of Na+ and K+ currents observed in whole-cell patch clamp recordings of mouse Grueneberg ganglion neurons in acute slices. Two distinct Na+ conductances representing the TTX-sensitive and TTX-resistant currents and one delayed rectifier K+ currrent are included. By modulating the maximal conductances of Na+ currents, one can reproduce the regular, phasic, and sporadic patterns of repetitive firing found in the patch clamp experiments.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Olfactory receptor GLU cell; Grueneberg ganglion neuron
Currents: I K; I K,leak; I Sodium
Model Concept(s): Action Potential Initiation; Temporal Pattern Generation; Action Potentials; Rebound firing; Recurrent Discharge; Olfaction
Simulation Environment: NEURON
Implementer(s): Liu, Cambrian [camliu at chla.usc.edu]
References:
Liu CY, Xiao C, Fraser SE, Lester HA, Koos DS. (2012). Electrophysiological characterization of Grueneberg ganglion olfactory neurons: spontaneous firing, sodium conductance, and hyperpolarization-activated currents. Journal of neurophysiology. 108 [PubMed]