SN-MN neurons of Aplysia (Zhou et al. 2014)

Contribution of PKC-dependent processes to the maintenance of short-term facilitation(STF) at SN-MN synapse of Aplysia were exmained. A computational model of transmitter release demonstrated that a PKC-dependent mobilization process was sufficient to explain the maintenance of STF at nondepressed synapses and the facilitation of depressed synapses.

Model Type: Synapse

Region(s) or Organism(s): Aplysia

Cell Type(s): Aplysia sensory neuron; Aplysia motor neuron

Currents: I Calcium

Transmitters: Glutamate

Model Concept(s): Short-term Synaptic Plasticity

Simulation Environment: C or C++ program

Implementer(s): Zhou, Lian [lian.zhou at]


Gingrich KJ, Byrne JH. (1985). Simulation of synaptic depression, posttetanic potentiation, and presynaptic facilitation of synaptic potentials from sensory neurons mediating gill-withdrawal reflex in Aplysia. Journal of neurophysiology. 53 [PubMed]

Zhou L, Baxter DA, Byrne JH. (2014). Contribution of PKC to the maintenance of 5-HT-induced short-term facilitation at sensorimotor synapses of Aplysia. Journal of neurophysiology. 112 [PubMed]

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