Contribution of PKC-dependent processes to the maintenance of short-term facilitation(STF) at SN-MN synapse of Aplysia were exmained. A computational model of transmitter release demonstrated that a PKC-dependent mobilization process was sufficient to explain the maintenance of STF at nondepressed synapses and the facilitation of depressed synapses.
Model Type: Synapse
Region(s) or Organism(s): Aplysia
Currents: I Calcium
Model Concept(s): Short-term Synaptic Plasticity
Simulation Environment: C or C++ program
Implementer(s): Zhou, Lian [lian.zhou at uth.tmc.edu]
Gingrich KJ, Byrne JH. (1985). Simulation of synaptic depression, posttetanic potentiation, and presynaptic facilitation of synaptic potentials from sensory neurons mediating gill-withdrawal reflex in Aplysia. Journal of neurophysiology. 53 [PubMed]