" ... We then introduce a minimal model that consists of learning at the parallel fibers to Purkinje cells with the help of the climbing fibers. Although the minimal model reproduces the behavior of the wild-type animals and is analytically tractable, it fails at reproducing the behavior of mutant mice and the electrophysiology data. Therefore, we build a detailed model involving plasticity at the parallel fibers to Purkinje cells' synapse guided by climbing fibers, feedforward inhibition of Purkinje cells, and plasticity at the mossy fiber to vestibular nuclei neuron synapse. The detailed model reproduces both the behavioral and electrophysiological data of both the wild-type and mutant mice and allows for experimentally testable predictions. "
Model Type: Realistic Network
Region(s) or Organism(s): Cerebellum
Cell Type(s): Cerebellum Purkinje GABA cell
Model Concept(s): Synaptic Plasticity
Simulation Environment: MATLAB
Implementer(s): Clopath, Claudia [c.clopath at imperial.ac.uk]
Clopath C, Badura A, De Zeeuw CI, Brunel N. (2014). A cerebellar learning model of vestibulo-ocular reflex adaptation in wild-type and mutant mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34 [PubMed]