Modeling hebbian and homeostatic plasticity (Toyoizumi et al. 2014)

"... We propose a model in which synaptic strength is the product of a synapse-specific Hebbian factor and a postsynaptic- cell-specific homeostatic factor, with each factor separately arriving at a stable inactive state. This model captures ODP dynamics and has plausible biophysical substrates. We confirm model predictions experimentally that plasticity is inactive at stable states and that synaptic strength overshoots during recovery from visual deprivation. ..."

Model Type: Realistic Network

Cell Type(s): Neocortex L2/3 pyramidal GLU cell

Model Concept(s): Development; Homeostasis; Hebbian plasticity

Simulation Environment: MATLAB


Toyoizumi T, Kaneko M, Stryker MP, Miller KD. (2014). Modeling the dynamic interaction of Hebbian and homeostatic plasticity. Neuron. 84 [PubMed]

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.