The mechanisms underlying generalized seizures are explored with neural field theory. A corticothalamic neural field model is used to explore changes leading to pathological seizure states. It is found that absence seizures arise from instabilities in the system and replicate experimental studies in numerous animal models and clinical studies.
Model Type: Neural mass
Model Concept(s): Epilepsy
Simulation Environment: MATLAB
References:
Zhao X, Robinson PA. (2015). Generalized seizures in a neural field model with bursting dynamics. Journal of computational neuroscience. 39 [PubMed]