This model reproduces the dynamic response of cold thermoreceptors, transiently changing the firing rate upon heating or cooling. It also displays the 'static' or adapted firing patterns observed in these receptors.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Dorsal Root Ganglion (DRG) cell; Dorsal Root Ganglion cell: cold sensing
Currents: I Na,p; I Na,t; I K; I K,Ca; I trp; I TRPM8
Model Concept(s): Bursting; Temporal Pattern Generation; Oscillations; Homeostasis; Temperature; Sensory coding
Simulation Environment: NEURON; Python
Implementer(s): Orio, Patricio [patricio.orio at uv.cl]
Olivares E et al. (2015). TRPM8-Dependent Dynamic Response in a Mathematical Model of Cold Thermoreceptor. PloS one. 10 [PubMed]