Effect of Polarization Induced by Non-Weak Electric Fields on the Excitability of Elongated Neurons With Active Dendrite. In response to polarization, the active currents in the dendrites of pyramidal neurons play a pivotal role in the excitability of elongated neurons. Depending on a number of parameters either hyperpolarizing or depolarizing currents in the dendrite dominate as polarization is increased. Furthermore, the impact that these active dendrite channels (Ca, KAHP, etc) occur when only a small fraction of their channels are open.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Hippocampus CA3 pyramidal GLU cell; Neocortex L5/6 pyramidal GLU cell; Neocortex L2/3 pyramidal GLU cell; Neocortex U1 L6 pyramidal corticalthalamic GLU cell; Neocortex layer 4 pyramidal cell
Model Concept(s): Extracellular Fields
Simulation Environment: MATLAB
Implementer(s): Barreto, Ernest
References:
Reznik RI, Barreto E, Sander E, So P. (2016). Effects of polarization induced by non-weak electric fields on the excitability of elongated neurons with active dendrites. Journal of computational neuroscience. 40 [PubMed]