" ... Here a model is developed that connects ongoing, competing processes of synaptic growth and weakening to stochastic processes of receptor insertion and removal in dendritic spines. The model simulates long-term (>1 yr) persistence of groups of strong synapses. A unimodal weight distribution results. For stability of this distribution it proved essential to incorporate resource competition between synapses organized into small clusters. ..."
Model Type: Synapse
Model Concept(s): Long-term Synaptic Plasticity
Simulation Environment: Java (web link to model)
Implementer(s): Smolen, Paul [paul.d.smolen at uth.tmc.edu]
References:
Smolen P. (2015). Modeling maintenance of long-term potentiation in clustered synapses: long-term memory without bistability. Neural plasticity. 2015 [PubMed]