Axonal HH-model for temperature stimulation (Fribance et al 2016)

"... To analyze the temperature effect, our study modified the classical HH axonal model by incorporating a membrane capacitance-temperature relationship. The modified model successfully simulated the generation and propagation of action potentials induced by a rapid increase in local temperature when the Curie temperature of membrane capacitance is below 40 °C, while the classical model failed to simulate the axonal excitation by temperature stimulation. The new model predicts that a rapid increase in local temperature produces a rapid increase in membrane capacitance, which causes an inward membrane current across the membrane capacitor strong enough to depolarize the membrane and generate an action potential. ..."

Model Type: Axon

Cell Type(s): Squid axon

Currents: I_K,Na

Model Concept(s): Action Potential Initiation

Simulation Environment: MATLAB

Implementer(s): Wang, Jicheng [jiw23 at]; Tai, Changfeng


Fribance S, Wang J, Roppolo JR, de Groat WC, Tai C. (2016). Axonal model for temperature stimulation. Journal of computational neuroscience. 41 [PubMed]

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