A mathematical model of evoked calcium dynamics in astrocytes (Handy et al 2017)

" ...Here we present a qualitative analysis of a recent mathematical model of astrocyte calcium responses. We show how the major response types are generated in the model as a result of the underlying bifurcation structure. By varying key channel parameters, mimicking blockers used by experimentalists, we manipulate this underlying bifurcation structure and predict how the distributions of responses can change. We find that store-operated calcium channels, plasma membrane bound channels with little activity during calcium transients, have a surprisingly strong effect, underscoring the importance of considering these channels in both experiments and mathematical settings. ..."

Model Type: Glia

Currents: Ca pump; I_SERCA; I Calcium

Receptors: IP3

Model Concept(s): Calcium dynamics; Oscillations; Bifurcation

Simulation Environment: MATLAB; XPPAUT

Implementer(s): Handy, Gregory [handy at math.utah.edu]; Taheri, Marsa


Handy G, Taheri M, White JA, Borisyuk A. (2017). Mathematical investigation of IP3-dependent calcium dynamics in astrocytes. Journal of computational neuroscience. 42 [PubMed]

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