An ionic model for Type 3 firing in neurons (Clay et al 2008) Some neurons fire only once in response to a sustained depolarizing current pulse, type 3 behavior. One example, surprisingly, is the squid giant axon. The Hodgkin-Huxley (HH) model of this preparation fires repetitively for these conditions – type 2, a result that is not observed experimentally as shown in the above paper. Changing one parameter of their model of IK is sufficient to mimic the result.
Model Type: Neuron or other electrically excitable cell
Simulation Environment: NEURON; Python
Implementer(s): Ganguly, Mohit [mohit.ganguly at vanderbilt.edu]; Clay, John R
References:
Clay JR, Paydarfar D, Forger DB. (2008). A simple modification of the Hodgkin and Huxley equations explains type 3 excitability in squid giant axons. Journal of the Royal Society, Interface. 5 [PubMed]