Hodgkin-Huxley style model for a neuron of the Suprachiasmatic Nucleus (SCN). Modified from DeWoskin et al, PNAS, 2015 to include a persistent sodium current. The model is used to study the role of the kinase GSK3 in regulating the electrical activity of SCN neurons through a persistent sodium current.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Suprachiasmatic nucleus (SCN) neuron
Currents: I Na,p; I Calcium; I K,Ca; I K,leak; I Na, leak
Simulation Environment: MATLAB
Implementer(s): DeWoskin, Daniel [dadewoskin at gmail.com]
References:
Paul JR et al. (2016). Regulation of persistent sodium currents by glycogen synthase kinase 3 encodes daily rhythms of neuronal excitability. Nature communications. 7 [PubMed]
DeWoskin D et al. (2015). Distinct roles for GABA across multiple timescales in mammalian circadian timekeeping. Proceedings of the National Academy of Sciences of the United States of America. 112 [PubMed]