Biophysically accurate models of six classes of C. elegans neurons: AIY, RIM, and AVA interneurons, and the VA, VB, and VD motor neurons. The implemented codes reproduce current-clamp and voltage-clamp experiments reported in literature and simulate knockout neurons, with the aim to identify the biophysical mechanisms at the basis of inter and motor neuron functioning. These models represent a step forward toward the modeling of C. elegans neuronal networks and virtual experiments on the nematode nervous system.
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s):
Cell Type(s): Abstract single compartment conductance based cell; Hodgkin-Huxley neuron
Currents: I Calcium; I Potassium; IK Bkca; IK Skca; Kir
Receptors:
Genes:
Transmitters:
Model Concept(s):
Simulation Environment: NEURON; Python
Implementer(s): Nicoletti, Martina
References:
Nicoletti M et al. (2024). Biophysical modeling of the whole-cell dynamics of C. elegans motor and interneurons families. PloS one. 19 [PubMed]