A biochemically detailed model of GABAB-receptor activation for pre- and postsynaptic domains. (Mäki-Marttunen et al., 2025)


Mass-action-law based model of GABAB-receptor activation and its effects on GIRK channel and N-type Ca2+ channel activity. The model is simulated as a single compartment model and integrated into multicompartmental models of hippocampal and neocortical pyramidal cells, as well as into presynaptic axon terminals.

Model Type: Axon; Channel/Receptor; Neuron or other electrically excitable cell

Region(s) or Organism(s):

Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Neocortex layer 5 pyramidal cell

Currents: I CAN; Kir

Receptors: AMPA; GabaB; NMDA

Genes:

Transmitters: Gaba; Glutamate

Model Concept(s):

Simulation Environment: NEURON

References:

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