The model of the inner retinal circuit including bipolar cells, AII amacrine cells, and ganglion cells. Those cells are connected by gap junctions, conventional synapses, and ribbon synapses that are newly proposed. Retinal activity in WT, rd1, mGluR6KO, and TrpM1KO retinae can be regenerated by changing the conditions.
Experimental motivation: mGluR6 and TrpM1 are responsible for signal transmission in the retinal ON pathway. However, TrpM1KO retina exhibits spontaneous oscillation observed in rd1 mouse retina whereas mGluR6KO retina does not. To understand difference between two different retinae is the research objective.
Model Type: Neuron or other electrically excitable cell; Realistic Network; Synapse
Region(s) or Organism(s): Retina
Cell Type(s): Retina amacrine cell; Retina bipolar GLU cell; Retina ganglion GLU cell
Currents:
Receptors: mGluR6
Genes:
Transmitters:
Model Concept(s): Oscillations
Simulation Environment: NEURON
Implementer(s): Kitano, Katsunori [kkt23219 at is.ritsumei.ac.jp]
References:
Horie S et al. (2025). A mechanism for pathological oscillations in mouse retinal ganglion cells in a model of night blindness. The Journal of general physiology. 157 [PubMed]