"Inhibitory avoidance (IA) training in rodents initiates a molecular cascade within hippocampal neurons. This cascade contributes to the transition of short- to long-term memory (i.e., consolidation). Here, a differential equation-based model was developed to describe a positive feedback loop within this molecular cascade. The feedback loop begins with an IA-induced release of brain-derived neurotrophic factor (BDNF), which in turn leads to rapid phosphorylation of the cAMP response element-binding protein (pCREB), and a subsequent increase in the level of the beta isoform of the CCAAT/enhancer binding protein (C/EBPbeta). ... " See paper for more.
Region(s) or Organism(s): Hippocampus
Model Concept(s): Signaling pathways
Simulation Environment: XPPAUT
Implementer(s): Zhang, Yili [Yili.Zhang at uth.tmc.edu]
References:
Zhang Y, Smolen P, Alberini CM, Baxter DA, Byrne JH. (2016). Computational model of a positive BDNF feedback loop in hippocampal neurons following inhibitory avoidance training. Learning & memory (Cold Spring Harbor, N.Y.). 23 [PubMed]