Model of a BDNF feedback loop (Zhang et al 2016)

"Inhibitory avoidance (IA) training in rodents initiates a molecular cascade within hippocampal neurons. This cascade contributes to the transition of short- to long-term memory (i.e., consolidation). Here, a differential equation-based model was developed to describe a positive feedback loop within this molecular cascade. The feedback loop begins with an IA-induced release of brain-derived neurotrophic factor (BDNF), which in turn leads to rapid phosphorylation of the cAMP response element-binding protein (pCREB), and a subsequent increase in the level of the beta isoform of the CCAAT/enhancer binding protein (C/EBPbeta). ... " See paper for more.

Region(s) or Organism(s): Hippocampus

Model Concept(s): Signaling pathways

Simulation Environment: XPPAUT

Implementer(s): Zhang, Yili [Yili.Zhang at]


Zhang Y, Smolen P, Alberini CM, Baxter DA, Byrne JH. (2016). Computational model of a positive BDNF feedback loop in hippocampal neurons following inhibitory avoidance training. Learning & memory (Cold Spring Harbor, N.Y.). 23 [PubMed]

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.