Model of a BDNF feedback loop (Zhang et al 2016)


Zhang Y, Smolen P, Alberini CM, Baxter DA, Byrne JH. (2016). Computational model of a positive BDNF feedback loop in hippocampal neurons following inhibitory avoidance training. Learning & memory (Cold Spring Harbor, N.Y.). 23 [PubMed]

See more from authors: Zhang Y · Smolen P · Alberini CM · Baxter DA · Byrne JH

References and models cited by this paper

Arthur JS et al. (2004). Mitogen- and stress-activated protein kinase 1 mediates cAMP response element-binding protein phosphorylation and activation by neurotrophins. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24 [PubMed]

Aslam N, Shouval HZ. (2012). Regulation of cytoplasmic polyadenylation can generate a bistable switch. BMC systems biology. 6 [PubMed]

Baldi E, Bucherelli C. (2015). Brain sites involved in fear memory reconsolidation and extinction of rodents. Neuroscience and biobehavioral reviews. 53 [PubMed]

Bambah-Mukku D, Travaglia A, Chen DY, Pollonini G, Alberini CM. (2014). A positive autoregulatory BDNF feedback loop via C/EBPß mediates hippocampal memory consolidation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34 [PubMed]

Bekinschtein P et al. (2007). Persistence of long-term memory storage requires a late protein synthesis- and BDNF- dependent phase in the hippocampus. Neuron. 53 [PubMed]

Bekinschtein P et al. (2010). Persistence of long-term memory storage: new insights into its molecular signatures in the hippocampus and related structures. Neurotoxicity research. 18 [PubMed]

Bhalla US, Iyengar R. (1999). Emergent properties of networks of biological signaling pathways. Science (New York, N.Y.). 283 [PubMed]

Bosch M et al. (2014). Structural and molecular remodeling of dendritic spine substructures during long-term potentiation. Neuron. 82 [PubMed]

Bourtchouladze R et al. (1998). Different training procedures recruit either one or two critical periods for contextual memory consolidation, each of which requires protein synthesis and PKA. Learning & memory (Cold Spring Harbor, N.Y.). 5 [PubMed]

Chen DY, Bambah-Mukku D, Pollonini G, Alberini CM. (2012). Glucocorticoid receptors recruit the CaMKIIa-BDNF-CREB pathways to mediate memory consolidation. Nature neuroscience. 15 [PubMed]

Chen WG et al. (2003). Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science (New York, N.Y.). 302 [PubMed]

Cheng A, Wang S, Cai J, Rao MS, Mattson MP. (2003). Nitric oxide acts in a positive feedback loop with BDNF to regulate neural progenitor cell proliferation and differentiation in the mammalian brain. Developmental biology. 258 [PubMed]

De Cesare D, Jacquot S, Hanauer A, Sassone-Corsi P. (1998). Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene. Proceedings of the National Academy of Sciences of the United States of America. 95 [PubMed]

Finsterwald C, Steinmetz AB, Travaglia A, Alberini CM. (2015). From Memory Impairment to Posttraumatic Stress Disorder-Like Phenotypes: The Critical Role of an Unpredictable Second Traumatic Experience. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35 [PubMed]

Grecksch G, Matthies H. (1980). Two sensitive periods for the amnesic effect of anisomycin. Pharmacology, biochemistry, and behavior. 12 [PubMed]

Guan JS et al. (2009). HDAC2 negatively regulates memory formation and synaptic plasticity. Nature. 459 [PubMed]

Hou L, Klann E. (2004). Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24 [PubMed]

Igaz LM, Vianna MR, Medina JH, Izquierdo I. (2002). Two time periods of hippocampal mRNA synthesis are required for memory consolidation of fear-motivated learning. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22 [PubMed]

Impey S et al. (1998). Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning. Nature neuroscience. 1 [PubMed]

Jain P, Bhalla US. (2009). Signaling logic of activity-triggered dendritic protein synthesis: an mTOR gate but not a feedback switch. PLoS computational biology. 5 [PubMed]

Khakpai F, Nasehi M, Zarrindast MR. (2016). The role of NMDA receptors of the medial septum and dorsal hippocampus on memory acquisition. Pharmacology, biochemistry, and behavior. 143 [PubMed]

Kojima M et al. (2001). Biological characterization and optical imaging of brain-derived neurotrophic factor-green fluorescent protein suggest an activity-dependent local release of brain-derived neurotrophic factor in neurites of cultured hippocampal neurons. Journal of neuroscience research. 64 [PubMed]

Kornisiuk E et al. (2011). Memory impairment in rats by hippocampal administration of the serine protease subtilisin. Behavioural brain research. 219 [PubMed]

Liu RY, Fioravante D, Shah S, Byrne JH. (2008). cAMP response element-binding protein 1 feedback loop is necessary for consolidation of long-term synaptic facilitation in Aplysia. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Maharana C, Sharma KP, Sharma SK. (2013). Feedback mechanism in depolarization-induced sustained activation of extracellular signal-regulated kinase in the hippocampus. Scientific reports. 3 [PubMed]

Martinowich K et al. (2003). DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science (New York, N.Y.). 302 [PubMed]

McDougal RA, Morse TM, Hines ML, Shepherd GM. (2015). ModelView for ModelDB: Online Presentation of Model Structure. Neuroinformatics. 13 [PubMed]

Milekic MH, Brown SD, Castellini C, Alberini CM. (2006). Persistent disruption of an established morphine conditioned place preference. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Miller P, Zhabotinsky AM, Lisman JE, Wang XJ. (2005). The stability of a stochastic CaMKII switch: dependence on the number of enzyme molecules and protein turnover. PLoS biology. 3 [PubMed]

Minichiello L. (2009). TrkB signalling pathways in LTP and learning. Nature reviews. Neuroscience. 10 [PubMed]

Ogasawara H, Kawato M. (2009). Bistable switches for synaptic plasticity. Science signaling. 2 [PubMed]

Ogasawara H, Kawato M. (2010). The protein kinase M? network as a bistable switch to store neuronal memory. BMC systems biology. 4 [PubMed]

Panja D, Bramham CR. (2014). BDNF mechanisms in late LTP formation: A synthesis and breakdown. Neuropharmacology. 76 Pt C [PubMed]

Parkin SE, Baer M, Copeland TD, Schwartz RC, Johnson PF. (2002). Regulation of CCAAT/enhancer-binding protein (C/EBP) activator proteins by heterodimerization with C/EBPgamma (Ig/EBP). The Journal of biological chemistry. 277 [PubMed]

Pettigrew DB, Smolen P, Baxter DA, Byrne JH. (2005). Dynamic properties of regulatory motifs associated with induction of three temporal domains of memory in aplysia. Journal of computational neuroscience. 18 [PubMed]

Radulovic J, Tronson NC. (2010). Molecular specificity of multiple hippocampal processes governing fear extinction. Reviews in the neurosciences. 21 [PubMed]

Redondo RL, Morris RG. (2011). Making memories last: the synaptic tagging and capture hypothesis. Nature reviews. Neuroscience. 12 [PubMed]

Santini E, Huynh TN, Klann E. (2014). Mechanisms of translation control underlying long-lasting synaptic plasticity and the consolidation of long-term memory. Progress in molecular biology and translational science. 122 [PubMed]

Shema R, Sacktor TC, Dudai Y. (2007). Rapid erasure of long-term memory associations in the cortex by an inhibitor of PKM zeta. Science (New York, N.Y.). 317 [PubMed]

Slipczuk L et al. (2009). BDNF activates mTOR to regulate GluR1 expression required for memory formation. PloS one. 4 [PubMed]

Smolen P, Baxter DA, Byrne JH. (2012). Molecular constraints on synaptic tagging and maintenance of long-term potentiation: a predictive model. PLoS computational biology. 8 [PubMed]

Tao X, Finkbeiner S, Arnold DB, Shaywitz AJ, Greenberg ME. (1998). Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. Neuron. 20 [PubMed]

Taubenfeld SM, Milekic MH, Monti B, Alberini CM. (2001). The consolidation of new but not reactivated memory requires hippocampal C/EBPbeta. Nature neuroscience. 4 [PubMed]

Taubenfeld SM et al. (2001). Fornix-dependent induction of hippocampal CCAAT enhancer-binding protein [beta] and [delta] Co-localizes with phosphorylated cAMP response element-binding protein and accompanies long-term memory consolidation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 21 [PubMed]

Tiunova AA, Anokhin KV, Rose SP. (1998). Two critical periods of protein and glycoprotein synthesis in memory consolidation for visual categorization learning in chicks. Learning & memory (Cold Spring Harbor, N.Y.). 4 [PubMed]

Tuvikene J, Pruunsild P, Orav E, Esvald EE, Timmusk T. (2016). AP-1 Transcription Factors Mediate BDNF-Positive Feedback Loop in Cortical Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 36 [PubMed]

Vaynman S, Ying Z, Gomez-Pinilla F. (2003). Interplay between brain-derived neurotrophic factor and signal transduction modulators in the regulation of the effects of exercise on synaptic-plasticity. Neuroscience. 122 [PubMed]

Wu X, Spiro C, Owen WG, McMurray CT. (1998). cAMP response element-binding protein monomers cooperatively assemble to form dimers on DNA. The Journal of biological chemistry. 273 [PubMed]

Zhang X et al. (2014). Positive feedback loop of autocrine BDNF from microglia causes prolonged microglia activation. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 34 [PubMed]

Zhang Y, Smolen P, Baxter DA, Byrne JH. (2010). The sensitivity of memory consolidation and reconsolidation to inhibitors of protein synthesis and kinases: computational analysis. Learning & memory (Cold Spring Harbor, N.Y.). 17 [PubMed]

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Solinas SMG, Edelmann E, Leßmann V, Migliore M. (2019). A kinetic model for Brain-Derived Neurotrophic Factor mediated spike timing-dependent LTP. PLoS computational biology. 15 [PubMed]

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