We tested the reproducibility and comparability of four astrocyte models (Manninen, Havela, Linne, 2017). Model by Lavrentovich and Hemkin (2008) was one of them. We implemented and ran the model by Lavrentovich and Hemkin (2008) using Jupyter Notebook. Model code produces results of Figure 1 in Manninen, Havela, Linne (2017).
Model Type: Glia
Region(s) or Organism(s): Generic
Cell Type(s): Astrocyte
Receptors: IP3
Model Concept(s): Calcium dynamics; Oscillations; Signaling pathways
Simulation Environment: Python
Implementer(s): Manninen, Tiina [tiina.h.manninen at gmail.com]
References:
Lavrentovich M, Hemkin S. (2008). A mathematical model of spontaneous calcium(II) oscillations in astrocytes. Journal of theoretical biology. 251 [PubMed]
Lavrentovich M, Hemkin S. (2009). Corrigendum to “A mathematical model of spontaneous calcium(II) oscillations in astrocytes” [J. Theor. Biol. 251 (2008) 553–560] Journal of Theoretical Biology. 260(2)
Manninen T, Havela R, Linne M-L. (2017). Reproducibility and comparability of computational models for astrocyte calcium excitability Front. Neuroinform..