Ca2+ oscillations in single astrocytes (Lavrentovich and Hemkin 2008) (python) (Manninen et al 2017)

We tested the reproducibility and comparability of four astrocyte models (Manninen, Havela, Linne, 2017). Model by Lavrentovich and Hemkin (2008) was one of them. We implemented and ran the model by Lavrentovich and Hemkin (2008) using Jupyter Notebook. Model code produces results of Figure 1 in Manninen, Havela, Linne (2017).

Model Type: Glia

Region(s) or Organism(s): Generic

Cell Type(s): Astrocyte

Receptors: IP3

Model Concept(s): Calcium dynamics; Oscillations; Signaling pathways

Simulation Environment: Python

Implementer(s): Manninen, Tiina [tiina.h.manninen at]


Lavrentovich M, Hemkin S. (2008). A mathematical model of spontaneous calcium(II) oscillations in astrocytes. Journal of theoretical biology. 251 [PubMed]

Lavrentovich M, Hemkin S. (2009). Corrigendum to “A mathematical model of spontaneous calcium(II) oscillations in astrocytes” [J. Theor. Biol. 251 (2008) 553–560] Journal of Theoretical Biology. 260(2)

Manninen T, Havela R, Linne M-L. (2017). Reproducibility and comparability of computational models for astrocyte calcium excitability Front. Neuroinform..

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