Spontaneous calcium oscillations in single astrocytes (Riera et al. 2011) (Manninen et al 2017)

We tested the reproducibility and comparability of four astrocyte models (Manninen, Havela, Linne, 2017). Model by Riera et al. (2011) was one of them. We implemented and ran the model by Riera et al. (2011) using Jupyter Notebook. Model codes produce results of Figures 1 and 2 in Manninen, Havela, Linne (2017).

Model Type: Glia

Region(s) or Organism(s): Hippocampus

Cell Type(s): Astrocyte

Receptors: IP3

Model Concept(s): Calcium dynamics; Oscillations; Signaling pathways

Simulation Environment: Python

Implementer(s): Manninen, Tiina [tiina.h.manninen at gmail.com]


Manninen T, Havela R, Linne M-L. (2017). Reproducibility and comparability of computational models for astrocyte calcium excitability Front. Neuroinform..

Riera J, Hatanaka R, Ozaki T, Kawashima R. (2011). Modeling the spontaneous Ca2+ oscillations in astrocytes: Inconsistencies and usefulness. Journal of integrative neuroscience. 10 [PubMed]

Riera J, Hatanaka R, Uchida T, Ozaki T, Kawashima R. (2011). Quantifying the uncertainty of spontaneous Ca2+ oscillations in astrocytes: particulars of Alzheimer's disease. Biophysical journal. 101 [PubMed]

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