Neural mass model of spindle generation in the isolated thalamus (Schellenberger Costa et al. 2016)

The model generates different oscillatory patterns in the thalamus, including delta and spindle band oscillations.

Model Type: Neural mass

Region(s) or Organism(s): Thalamus

Cell Type(s): Thalamus reticular nucleus GABA cell; Thalamus geniculate nucleus/lateral principal GLU cell

Currents: I K,Ca; I Calcium

Receptors: Gaba; AMPA; NMDA

Model Concept(s): Calcium dynamics; Sleep; Activity Patterns; Oscillations; Bifurcation; Spindles; Audition

Simulation Environment: Network; C or C++ program (web link to model); MATLAB (web link to model)

Implementer(s): Schellenberger Costa, Michael [mschellenbergercosta at gmail.com]

References:

Weigenand A, Schellenberger Costa M, Ngo HV, Claussen JC, Martinetz T. (2014). Characterization of K-complexes and slow wave activity in a neural mass model. PLoS computational biology. 10 [PubMed]

Schellenberger Costa M et al. (2016). A Thalamocortical Neural Mass Model of the EEG during NREM Sleep and Its Response to Auditory Stimulation. PLoS computational biology. 12 [PubMed]