Nicotinic control of dopamine release in nucleus accumbens (Maex et al. 2014)


MaexEtAl2014/Fig2/Fig2B.ode

bas_nic 0
C_ach 20
C_basDop 0.1
dose_Aga7 0.3
dose_Nic 5
EC50_A7 80
EC50_A7ach 68
EC50_A7ag 0.03
EC50_A7nic 13
EC50_actB2 30
EC50_B2ach 30
EC50_B2ag 30
EC50_B2nic 0.23
EC50_desB2 0.061
EC50_Rdop 0.2
Hill_actA7 1.73
Hill_actB2 1.05
Hill_desA7 2
Hill_desB2 0.5
Htau_desB2 3
I_basDop 0.1
I_basGab -0.05
IC50_A7ag 0.002
IC50_A7nic 1.3
Ktau_desB2 0.11
P_a7bas 0.01
r 0.8
s 0.8
tau1_agA7 10
tau1_nic 10
tau2_agA7 10
tau2_nic 10
tau_actA7 0.005
tau_actB2 0.005
tau_agB2 10
tau_Rdop 0.2
tau_Vdop 0.02
tau_Vgab 0.02
tmax_desA7 120
tmax_desB2 600
tmin_desA7 0.05
tmin_desB2 0.5
V_glu 0.1
Vmax_Rdop 1.3
w_actAgA7 0.3
w_actAgB2 1
w_actNicA7 0.8
w_actNicB2 2
w_gab 1.5
w_glu 1

MaexEtAl2014/Fig3/Fig3B.ode

bas_nic 0
C_ach 10
C_basDop 0.1
dose_Aga7 0.5
dose_nic 1
EC50_A7 80
EC50_A7ach 68
EC50_A7ag 0.03
EC50_A7nic 13
EC50_actB2 30
EC50_B2ach 30
EC50_B2ag 30
EC50_B2nic 0.23
EC50_desB2 0.061
EC50_Rdop 0.2
Hill_actA7 1.73
Hill_actB2 1.05
Hill_desA7 2
Hill_desB2 0.5
Htau_desB2 3
I_basDop 0.1
I_basGab -0.05
IC50_A7ag 0.002
IC50_A7nic 1.3
Ktau_desB2 0.11
P_a7bas 0.01
r 0.7
s 0
tau1_agA7 10
tau1_nic 10
tau2_agA7 100
tau2_nic 10
tau_actA7 0.005
tau_actB2 0.005
tau_agB2 10
tau_Rdop 0.2
tau_Vdop 0.02
tau_Vgab 0.02
tmax_desA7 120
tmax_desB2 600
tmin_desA7 0.05
tmin_desB2 0.5
V_glu 0.1
Vmax_Rdop 1.3
w_actAgA7 0.3
w_actAgB2 1
w_actNicA7 0.8
w_actNicB2 2
w_gab 1.5
w_glu 1

MaexEtAl2014/Fig6/Fig6.ode

bas_nic 0
C_ach 3
C_basDop 0.5
C_chol 30
dose_Aga7 4
dose_Nic 500
EC50_A7 80
EC50_A7ach 68
EC50_A7ag 0.03
EC50_A7nic 13
EC50_actB2 30
EC50_B2ach 30
EC50_B2ag 30
EC50_B2nic 0.23
EC50_desB2 0.061
EC50_Rdop 0.2
Hill_actA7 1.73
Hill_actB2 1.05
Hill_desA7 2
Hill_desB2 0.5
Htau_desB2 3
I_basDop 0.1
I_basGab -0.05
IC50_A7ag 0.002
IC50_A7nic 1.3
Ktau_desB2 0.11
P_a7bas 0.01
r 0.8
s 0.8
tau1_agA7 10
tau1_nic 10
tau2_agA7 200
tau2_nic 200
tau_actA7 0.005
tau_actB2 0.005
tau_agB2 10
tau_Rdop 0.2
tau_Vdop 0.02
tau_Vgab 0.02
tmax_desA7 120
tmax_desB2 600
tmin_desA7 0.05
tmin_desB2 0.5
V_glu 0.1
Vmax_Rdop 1.3
w_actAgA7 0.3
w_actAgB2 1
w_actNicA7 0.8
w_actNicB2 2
w_gab 1
w_glu 1

MaexEtAl2014/FigS4/FigS4-Aleft.ode

bas_nic 0
C_ach 20
C_basDop 0.1
dose_Aga7 0.3
dose_Nic 5
EC50_A7 80
EC50_A7ach 68
EC50_A7ag 0.03
EC50_A7nic 13
EC50_actB2 30
EC50_B2ach 30
EC50_B2ag 30
EC50_B2nic 0.23
EC50_desB2 0.061
EC50_Rdop 0.2
Hill_actA7 1.73
Hill_actB2 1.05
Hill_desA7 2
Hill_desB2 0.5
Htau_desB2 3
I_basDop 0.1
I_basGab -0.05
IC50_A7ag 0.002
IC50_A7nic 1.3
Ktau_desB2 0.11
P_a7bas 0.01
r 0.8
s 0.8
tau1_agA7 10
tau1_nic 10
tau2_agA7 10
tau2_nic 10
tau_actA7 0.005
tau_actB2 0.005
tau_agB2 10
tau_Rdop 0.2
tau_Vdop 0.02
tau_Vgab 0.02
tmax_desA7 120
tmax_desB2 600
tmin_desA7 0.05
tmin_desB2 0.5
V_glu 0.1
Vmax_Rdop 1.3
w_actAgA7 0.3
w_actAgB2 1
w_actNicA7 0.8
w_actNicB2 2
w_gab 1.5
w_glu 1

MaexEtAl2014/FigS4/FigS4-Aright.ode

bas_nic 0
C_ach 0
C_basDop 0.1
dose_Aga7 0.5
dose_nic 1
EC50_A7 80
EC50_A7ach 68
EC50_A7ag 0.03
EC50_A7nic 13
EC50_actB2 30
EC50_B2ach 30
EC50_B2ag 30
EC50_B2nic 0.23
EC50_desB2 0.061
EC50_Rdop 0.2
Hill_actA7 1.73
Hill_actB2 1.05
Hill_desA7 2
Hill_desB2 0.5
Htau_desB2 3
I_basDop 0.1
I_basGab -0.05
IC50_A7ag 0.002
IC50_A7nic 1.3
Ktau_desB2 0.11
P_a7bas 0.01
r 0.7
s 0
tau1_agA7 10
tau1_nic 10
tau2_agA7 100
tau2_nic 10
tau_actA7 0.005
tau_actB2 0.005
tau_agB2 10
tau_Rdop 0.2
tau_Vdop 0.02
tau_Vgab 0.02
tmax_desA7 120
tmax_desB2 600
tmin_desA7 0.05
tmin_desB2 0.5
V_glu 0.1
Vmax_Rdop 1.3
w_actAgA7 0.3
w_actAgB2 1
w_actNicA7 0.8
w_actNicB2 2
w_gab 1.5
w_glu 1

MaexEtAl2014/FigS4/FigS4-Bleft.ode

bas_nic 0
C_ach 20
C_basDop 0.1
dose_Aga7 0.3
dose_Nic 5
EC50_A7 80
EC50_A7ach 68
EC50_A7ag 0.03
EC50_A7nic 13
EC50_actB2 30
EC50_B2ach 30
EC50_B2ag 30
EC50_B2nic 0.23
EC50_desB2 0.061
EC50_Rdop 0.2
Hill_actA7 1.73
Hill_actB2 1.05
Hill_desA7 2
Hill_desB2 0.5
Htau_desB2 3
I_basDop 0.1
I_basGab -0.05
IC50_A7ag 0.002
IC50_A7nic 1.3
Ktau_desB2 0.11
P_a7bas 0.01
r 0.8
s 0.8
tau1_agA7 10
tau1_nic 10
tau2_agA7 10
tau2_nic 10
tau_actA7 0.005
tau_actB2 0.005
tau_agB2 10
tau_Rdop 0.2
tau_Vdop 0.02
tau_Vgab 0.02
tmax_desA7 120
tmax_desB2 600
tmin_desA7 0.05
tmin_desB2 0.5
V_glu 0.1
Vmax_Rdop 1.3
w_actAgA7 0.3
w_actAgB2 1
w_actNicA7 0.8
w_actNicB2 2
w_gab 1.5
w_glu 1

MaexEtAl2014/FigS4/FigS4-Bright.ode

bas_nic 0
C_ach 0
C_basDop 0.1
dose_Aga7 0.5
dose_nic 1
EC50_A7 80
EC50_A7ach 68
EC50_A7ag 0.03
EC50_A7nic 13
EC50_actB2 30
EC50_B2ach 30
EC50_B2ag 30
EC50_B2nic 0.23
EC50_desB2 0.061
EC50_Rdop 0.2
Hill_actA7 1.73
Hill_actB2 1.05
Hill_desA7 2
Hill_desB2 0.5
Htau_desB2 3
I_basDop 0.1
I_basGab -0.05
IC50_A7ag 0.002
IC50_A7nic 1.3
Ktau_desB2 0.11
P_a7bas 0.01
r 0.7
s 0
tau1_agA7 10
tau1_nic 10
tau2_agA7 100
tau2_nic 10
tau_actA7 0.005
tau_actB2 0.005
tau_agB2 10
tau_Rdop 0.2
tau_Vdop 0.02
tau_Vgab 0.02
tmax_desA7 120
tmax_desB2 600
tmin_desA7 0.05
tmin_desB2 0.5
V_glu 0.1
Vmax_Rdop 1.3
w_actAgA7 0.3
w_actAgB2 1
w_actNicA7 0.8
w_actNicB2 2
w_gab 1.5
w_glu 1

MaexEtAl2014/FigS4/FigS4-Cleft.ode

bas_nic 0
C_ach 20
C_basDop 0.1
dose_Aga7 0.3
dose_Nic 5
EC50_A7 80
EC50_A7ach 68
EC50_A7ag 0.03
EC50_A7nic 13
EC50_actB2 30
EC50_B2ach 30
EC50_B2ag 30
EC50_B2nic 0.23
EC50_desB2 0.061
EC50_Rdop 0.2
Hill_actA7 1.73
Hill_actB2 1.05
Hill_desA7 2
Hill_desB2 0.5
Htau_desB2 3
I_basDop 0.1
I_basGab -0.05
IC50_A7ag 0.002
IC50_A7nic 1.3
Ktau_desB2 0.11
P_a7bas 0.01
r 0.8
s 0.8
tau1_agA7 10
tau1_nic 10
tau2_agA7 10
tau2_nic 10
tau_actA7 0.005
tau_actB2 0.005
tau_agB2 10
tau_Rdop 0.2
tau_Vdop 0.02
tau_Vgab 0.02
tmax_desA7 120
tmax_desB2 600
tmin_desA7 0.05
tmin_desB2 0.5
V_glu 0.1
Vmax_Rdop 1.3
w_actAgA7 0.3
w_actAgB2 1
w_actNicA7 0.8
w_actNicB2 2
w_gab 1.5
w_glu 1

MaexEtAl2014/FigS4/FigS4-Cright.ode

bas_nic 0
C_ach 0
C_basDop 0.1
dose_Aga7 0.5
dose_nic 1
EC50_A7 80
EC50_A7ach 68
EC50_A7ag 0.03
EC50_A7nic 13
EC50_actB2 30
EC50_B2ach 30
EC50_B2ag 30
EC50_B2nic 0.23
EC50_desB2 0.061
EC50_Rdop 0.2
Hill_actA7 1.73
Hill_actB2 1.05
Hill_desA7 2
Hill_desB2 0.5
Htau_desB2 3
I_basDop 0.1
I_basGab -0.05
IC50_A7ag 0.002
IC50_A7nic 1.3
Ktau_desB2 0.11
P_a7bas 0.01
r 0.7
s 0
tau1_agA7 10
tau1_nic 10
tau2_agA7 100
tau2_nic 10
tau_actA7 0.005
tau_actB2 0.005
tau_agB2 10
tau_Rdop 0.2
tau_Vdop 0.02
tau_Vgab 0.02
tmax_desA7 120
tmax_desB2 600
tmin_desA7 0.05
tmin_desB2 0.5
V_glu 0.1
Vmax_Rdop 1.3
w_actAgA7 0.3
w_actAgB2 1
w_actNicA7 0.8
w_actNicB2 2
w_gab 1.5
w_glu 1

MaexEtAl2014/FigS4/FigS4-Dleft.ode

bas_nic 0
C_ach 20
C_basDop 0.1
dose_Aga7 0.3
dose_Nic 5
EC50_A7 80
EC50_A7ach 68
EC50_A7ag 0.03
EC50_A7nic 13
EC50_actB2 30
EC50_B2ach 30
EC50_B2ag 30
EC50_B2nic 0.23
EC50_desB2 0.061
EC50_Rdop 0.2
Hill_actA7 1.73
Hill_actB2 1.05
Hill_desA7 2
Hill_desB2 0.5
Htau_desB2 3
I_basDop 0.1
I_basGab -0.05
IC50_A7ag 0.002
IC50_A7nic 1.3
Ktau_desB2 0.11
P_a7bas 0.01
r 0.8
s 0.8
tau1_agA7 10
tau1_nic 10
tau2_agA7 10
tau2_nic 10
tau_actA7 0.005
tau_actB2 0.005
tau_agB2 10
tau_Rdop 0.2
tau_Vdop 0.02
tau_Vgab 0.02
tmax_desA7 120
tmax_desB2 600
tmin_desA7 0.05
tmin_desB2 0.5
V_glu 0.1
Vmax_Rdop 1.3
w_actAgA7 0.3
w_actAgB2 1
w_actNicA7 0.8
w_actNicB2 2
w_gab 1.5
w_glu 1

MaexEtAl2014/FigS4/FigS4-Dright.ode

bas_nic 0
C_ach 0
C_basDop 0.1
dose_Aga7 0.5
dose_nic 1
EC50_A7 80
EC50_A7ach 68
EC50_A7ag 0.03
EC50_A7nic 13
EC50_actB2 30
EC50_B2ach 30
EC50_B2ag 30
EC50_B2nic 0.23
EC50_desB2 0.061
EC50_Rdop 0.2
Hill_actA7 1.73
Hill_actB2 1.05
Hill_desA7 2
Hill_desB2 0.5
Htau_desB2 3
I_basDop 0.1
I_basGab -0.05
IC50_A7ag 0.002
IC50_A7nic 1.3
Ktau_desB2 0.11
P_a7bas 0.01
r 0.7
s 0
tau1_agA7 10
tau1_nic 10
tau2_agA7 100
tau2_nic 10
tau_actA7 0.005
tau_actB2 0.005
tau_agB2 10
tau_Rdop 0.2
tau_Vdop 0.02
tau_Vgab 0.02
tmax_desA7 120
tmax_desB2 600
tmin_desA7 0.05
tmin_desB2 0.5
V_glu 0.1
Vmax_Rdop 1.3
w_actAgA7 0.3
w_actAgB2 1
w_actNicA7 0.8
w_actNicB2 2
w_gab 1.5
w_glu 1

MaexEtAl2014/FigS5/FigS5A.ode

bas_ach 0
bas_chol 0
bas_nic 0
C_basDop 0.1
crossactA7 0.3
crosssenA7 0
dose_ach 0
dose_Aga7 0.003
dose_chol 1
dose_Nic 0
EC50_A7 80
EC50_A7ach 68
EC50_A7ag 0.03
EC50_A7nic 13
EC50_actB2 30
EC50_B2ach 30
EC50_B2ag 30
EC50_B2nic 0.23
EC50_desB2 0.061
EC50_Rdop 0.2
Hill_actA7 1.73
Hill_actB2 1.05
Hill_desA7 2
Hill_desB2 0.5
Htau_desB2 3
I_basDop 0.1
I_basGab -0.05
IC50_A7ach 1.3
IC50_A7ag 0.002
IC50_A7nic 1.3
Ktau_desB2 0.11
P_a7bas 0.01
r 0.8
s 0.8
stim_ach 0
tau1_agA7 10
tau1_nic 10
tau2_agA7 10
tau2_nic 10
tau_actA7 0.005
tau_actB2 0.005
tau_agB2 10
tau_Rdop 0.2
tau_Vdop 0.02
tau_Vgab 0.02
tmax_desA7 120
tmax_desB2 600
tmin_desA7 0.05
tmin_desB2 0.5
V_glu 0.1
Vmax_Rdop 1.3
w_actAgA7 0
w_actAgB2 1
w_actNicA7 0.8
w_actNicB2 2
w_gab 1.5
w_glu 1

MaexEtAl2014/FigS5/FigS5B.ode

bas_ACh 0
bas_chol 0
bas_nic 0
C_ach 0
C_basDop 0.1
crossactA7 0
crosssenA7 0
dose_Aga7 0.003
dose_chol 60
dose_Nic 0
EC50_A7 80
EC50_A7ach 68
EC50_A7ag 0.3
EC50_A7nic 13
EC50_actB2 30
EC50_B2ach 30
EC50_B2ag 30
EC50_B2nic 0.23
EC50_desB2 0.061
EC50_Rdop 0.2
Hill_actA7 1.73
Hill_actB2 1.05
Hill_desA7 2
Hill_desB2 0.5
Htau_desB2 3
I_basDop 0.1
I_basGab -0.05
IC50_A7ach 1.3
IC50_A7ag 0.002
IC50_A7nic 1.3
Ktau_desB2 0.11
P_a7bas 0.01
r 0.8
s 0.8
tau1_agA7 10
tau1_nic 10
tau2_agA7 10
tau2_nic 10
tau_actA7 0.005
tau_actB2 0.005
tau_agB2 10
tau_Rdop 0.2
tau_Vdop 0.02
tau_Vgab 0.02
tmax_desA7 120
tmax_desB2 600
tmin_desA7 0.05
tmin_desB2 0.5
V_glu 0.1
Vmax_Rdop 1.3
w_actAgA7 0.3
w_actAgB2 1
w_actNicA7 0.8
w_actNicB2 2
w_gab 1.5
w_glu 1
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