Model for concentration invariant odor coding based on primacy hypothesis (Wilson et al 2017)

"... Here we propose that, in olfaction, a small and relatively stable set comprised of the earliest activated receptors forms a code for concentration-invariant odor identity. One prediction of this “primacy coding” scheme is that decisions based on odor identity can be made solely using early odor-evoked neural activity. Using an optogenetic masking paradigm, we define the sensory integration time necessary for odor identification and demonstrate that animals can use information occurring <100ms after inhalation onset to identify odors. ... We propose a computational model demonstrating how such a code can be read by neural circuits of the olfactory system."

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Mouse

Cell Type(s): Olfactory bulb main mitral GLU cell

Receptors: Gaseous Receptors

Transmitters: Gaba

Model Concept(s): Activity Patterns; Olfaction

Simulation Environment: MATLAB

Implementer(s): Koulakov, Alexei [akula at]


Wilson CD, Serrano GO, Koulakov AA, Rinberg D. (2017). A primacy code for odor identity. Nature communications. 8 [PubMed]

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