Models of the neuron, planar (GPµE) and mushroom-shaped (GMµE) microelectrodes, neuro-electronic junction (microelectrode-electrolyte interface, cleft effect, and protein-glycocalyx electric double layer) are presented. Then, neuronal electrical activity is simulated by HSPICE software, and analyzed as a function of the most sensitive biophysical models parameters such as the neuron-microelectrode cleft width, spreading and seal resistances, ion-channel densities, double-layer properties, and microelectrode geometries.
Model Type: Extracellular
Cell Type(s): Hodgkin-Huxley neuron
Model Concept(s): Methods
Massobrio G, Martinoia S, Massobrio P. (2018). Equivalent Circuit of the Neuro-Electronic Junction for Signal Recordings From Planar and Engulfed Micro-Nano-Electrodes. IEEE transactions on biomedical circuits and systems. 12 [PubMed]