"The granular layer, which mainly consists of granule and Golgi cells, is the first stage of the cerebellar cortex and processes spatiotemporal information transmitted by mossy fiber inputs with a wide variety of firing patterns. To study its dynamics at multiple time scales in response to inputs approximating real spatiotemporal patterns, we constructed a large-scale 3D network model of the granular layer. ..."
Model Type: Realistic Network
Region(s) or Organism(s): Cerebellum
Cell Type(s): Cerebellum golgi cell
Currents: I A; I Calcium; I K; I K,Ca; I Na,t; I h; I Na,p; I T low threshold
Model Concept(s): Spatio-temporal Activity Patterns; Oscillations; Synchronization; Winner-take-all
Simulation Environment: NEURON
Implementer(s): Hong, Sungho [shhong at oist.jp]; Guo, Daqing [dqguo at uestc.edu.cn]; Raikov, Ivan [ivan.g.raikov at gmail.com]; Publio, Rodrigo [publio at oist.jp]; De Schutter, Erik [erik at oist.jp]
References:
Sudhakar SK et al. (2017). Spatiotemporal network coding of physiological mossy fiber inputs by the cerebellar granular layer. PLoS computational biology. 13 [PubMed]