"A resurgence has taken place in recent years in the use of the extracellularly recorded local field potential (LFP) to investigate neural network activity. To probe monosynaptic thalamic activation of cortical postsynaptic target cells, so called spike-trigger-averaged LFP (stLFP) signatures have been measured. In these experiments, the cortical LFP is measured by multielectrodes covering several cortical lamina and averaged on spontaneous spikes of thalamocortical (TC) cells. Using a well established forward-modeling scheme, we investigated the biophysical origin of this stLFP signature with simultaneous synaptic activation of cortical layer-4 neurons, mimicking the effect of a single afferent spike from a single TC neuron. ..."
Simulation Environment: NEURON (web link to model)
Hagen E et al. (2017). Focal Local Field Potential Signature of the Single-Axon Monosynaptic Thalamocortical Connection. The Journal of neuroscience : the official journal of the Society for Neuroscience. 37 [PubMed]