A biophysical model of vestibular ganglion neurons (Hight & Kalluri 2016, Ventura & Kalluri 2018)

A single compartment model in Matlab to represent vestibular ganglion neurons' somatic ion channels and their influence on firing patterns. Model is connected to a synthetic synaptic conductance to examine the relative influence of synaptic inputs and low-voltage gated potassium conductances on spike patterns.

Model Type: Synapse

Cell Type(s): Abstract integrate-and-fire leaky neuron; Abstract integrate-and-fire leaky neuron with dendritic subunits; Abstract single compartment conductance based cell; Vestibular neuron; Turtle vestibular neuron

Currents: I Potassium; I Na,t; I Sodium; I A; I h; I_KLT; I_KHT

Transmitters: Glutamate

Model Concept(s): Simplified Models; Activity Patterns

Simulation Environment: MATLAB

Implementer(s): Hight, Ariel E. ; Kalluri, Radha [radha at usc.edu]; Ventura, Christopher M.


Hight AE, Kalluri R. (2016). A biophysical model examining the role of low-voltage-activated potassium currents in shaping the responses of vestibular ganglion neurons. Journal of neurophysiology. 116 [PubMed]

Rothman JS, Manis PB. (2003). The roles potassium currents play in regulating the electrical activity of ventral cochlear nucleus neurons. Journal of neurophysiology. 89 [PubMed]

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