Human sleep-wake regulatory network model (Gleit et al 2013, Booth et al 2017)

A physiologically-based mathematical model of a sleep-wake regulatory network model for human sleep. The model simulates neurotransmitter-mediated interactions among hypothalamic and brainstem neuronal populations that promote wake, rapid eye movement (REM) sleep and non-REM (NREM) sleep. A neuronal population firing rate model formalism is used. The circadian rhythm pacemaker neuronal population, the suprachiasmatic nucleus (SCN), modulates activity in the wake- and sleep-promoting populations to entrain sleep-wake behavior to the ~24h circadian rhythm. A circadian clock oscillator model drives a 24h variation in the SCN firing rate and can be entrained to an externally imposed light:dark cycle. The default parameters replicate typical human sleep entrained to an external 14h:10h light:dark cycle

Region(s) or Organism(s): Brainstem

Model Concept(s): Sleep

Simulation Environment: MATLAB

Implementer(s): Booth, Victoria [vbooth at]


Gleit RD, Diniz Behn CG, Booth V. (2013). Modeling interindividual differences in spontaneous internal desynchrony patterns. Journal of biological rhythms. 28 [PubMed]

Booth V, Xique I, Diniz Behn C. (2017). One-Dimensional Map for the Circadian Modulation of Sleep in a Sleep-Wake Regulatory Network Model for Human Sleep SIAM Journal on Applied Dynamical Systems. 16

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