The human auditory periphery model can simulate single-unit response of basilar-membrane vibration, IHC receptor potential, instantaneous AN/CN/IC firing rates, as well as population responses such as otoacoustic emissions, auditory brainstem responses. The neuron models (IHC, AN,CN,IC) can be run independently to relate their responses to electrophysiology, or be simulated as part of the human auditory periphery.
Cell Type(s): Cochlea hair inner GLU cell; Cochlear nucleus bushy GLU cell; Auditory nerve; Brainstem neuron
Simulation Environment: Python; MATLAB
Implementer(s): Verhulst, Sarah [s.verhulst at ugent.be]; Altoé, Alessandro
References:
Verhulst S, Altoè A, Vasilkov V. (2018). Computational modeling of the human auditory periphery: Auditory-nerve responses, evoked potentials and hearing loss. Hearing research. 360 [PubMed]
Altoè A, Pulkki V, Verhulst S. (2018). The effects of the activation of the inner-hair-cell basolateral K+ channels on auditory nerve responses. Hearing research. 364 [PubMed]
Altoè A, Pulkki V, Verhulst S. (2014). Transmission line cochlear models: improved accuracy and efficiency. The Journal of the Acoustical Society of America. 136 [PubMed]
Verhulst S, Dau T, Shera CA. (2012). Nonlinear time-domain cochlear model for transient stimulation and human otoacoustic emission. The Journal of the Acoustical Society of America. 132 [PubMed]