Pacemaker neurons and respiratory rhythm generation (Purvis et al 2007)

"The pre-Botzinger complex (pBC) is a vital subcircuit of the respiratory central pattern generator. Although the existence of neurons with pacemaker-like bursting properties in this network is not questioned, their role in network rhythmogenesis is unresolved. ... We modeled the parameter variability of experimental data from pBC bursting pacemaker and nonpacemaker neurons using a modified version of our previously developed pBC neuron and network models. ... " The paper contains network modeling results that are not represented in this model entry. Only the neuron models are included in this modeldb entry.

Model Type: Neuron or other electrically excitable cell

Currents: I Na,p; I Na,t; I K

Model Concept(s): Oscillations; Temporal Pattern Generation; Activity Patterns; Bursting; Pacemaking mechanism

Simulation Environment: CellML (web link to model)


Purvis LK, Smith JC, Koizumi H, Butera RJ. (2007). Intrinsic bursters increase the robustness of rhythm generation in an excitatory network. Journal of neurophysiology. 97 [PubMed]

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