Respiratory central pattern generator (mammalian brainstem) (Rubin & Smith 2019)

This model includes a conditional respiratory pacemaker unit (representing the pre-Botzinger Complex), which can be tuned across oscillatory and non-oscillatory dynamic regimes in isolation, embedded into a full respiratory network. The work shows that under this embedding, the pacemaker unit's dynamics become masked: the network exhibits similar dynamical properties regardless of the conditional pacemaker node's tuning, and that node's outputs are dominated by network influences.

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Brainstem

Cell Type(s): PreBotzinger complex neuron

Currents: I Na,p

Receptors: AMPA; GabaA

Transmitters: Glutamate; Gaba

Model Concept(s): Respiratory control

Simulation Environment: XPPAUT

Implementer(s): Rubin, Jonathan E [jonrubin at]


Rubin JE, Smith JC. (2019). Robustness of respiratory rhythm generation across dynamic regimes. PLoS computational biology. 15 [PubMed]

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