Inhibitory control of motoneuron excitability (Venugopal et al 2011)


Venugopal S, Hamm TM, Crook SM, Jung R. (2011). Modulation of inhibitory strength and kinetics facilitates regulation of persistent inward currents and motoneuron excitability following spinal cord injury. Journal of neurophysiology. 106 [PubMed]

See more from authors: Venugopal S · Hamm TM · Crook SM · Jung R

References and models cited by this paper

Adams MM, Hicks AL. (2005). Spasticity after spinal cord injury. Spinal cord. 43 [PubMed]

BROOKS VB, WILSON VJ. (1958). Localization of stretch reflexes by recurrent inhibition. Science (New York, N.Y.). 127 [PubMed]

Bareyre FM, Schwab ME. (2003). Inflammation, degeneration and regeneration in the injured spinal cord: insights from DNA microarrays. Trends in neurosciences. 26 [PubMed]

Bennett DJ, Hultborn H, Fedirchuk B, Gorassini M. (1998). Synaptic activation of plateaus in hindlimb motoneurons of decerebrate cats. Journal of neurophysiology. 80 [PubMed]

Bennett DJ, Li Y, Siu M. (2001). Plateau potentials in sacrocaudal motoneurons of chronic spinal rats, recorded in vitro. Journal of neurophysiology. 86 [PubMed]

Boorman GI, Lee RG, Becker WJ, Windhorst UR. (1996). Impaired "natural reciprocal inhibition" in patients with spasticity due to incomplete spinal cord injury. Electroencephalography and clinical neurophysiology. 101 [PubMed]

Booth V, Jung R, Graham J. (2005). Modeling motoneurons after spinal cord injury: Persistent inward currents and plateau potentials Neurocomputing. 65-66

Booth V, Rinzel J. (1995). A minimal, compartmental model for a dendritic origin of bistability of motoneuron firing patterns. Journal of computational neuroscience. 2 [PubMed]

Booth V, Rinzel J, Kiehn O. (1997). Compartmental model of vertebrate motoneurons for Ca2+-dependent spiking and plateau potentials under pharmacological treatment. Journal of neurophysiology. 78 [PubMed]

Bose P, Parmer R, Reier PJ, Thompson FJ. (2005). Morphological changes of the soleus motoneuron pool in chronic midthoracic contused rats. Experimental neurology. 191 [PubMed]

Boulenguez P et al. (2010). Down-regulation of the potassium-chloride cotransporter KCC2 contributes to spasticity after spinal cord injury. Nature medicine. 16 [PubMed]

Bui TV, Grande G, Rose PK. (2008). Relative location of inhibitory synapses and persistent inward currents determines the magnitude and mode of synaptic amplification in motoneurons. Journal of neurophysiology. 99 [PubMed]

Bui TV, Grande G, Rose PK. (2008). Multiple modes of amplification of synaptic inhibition to motoneurons by persistent inward currents. Journal of neurophysiology. 99 [PubMed]

Carlin KP, Jones KE, Jiang Z, Jordan LM, Brownstone RM. (2000). Dendritic L-type calcium currents in mouse spinal motoneurons: implications for bistability. The European journal of neuroscience. 12 [PubMed]

Chen XY, Wolpaw JR. (1994). Triceps surae motoneuron morphology in the rat: a quantitative light microscopic study. The Journal of comparative neurology. 343 [PubMed]

Crook SM, Jung R, Venugopal S, Kurian M. (2009). Role of inhibition in the suppression of alpha motoneuron hyper-excitability following chronic incomplete spinal cord injury BMC Neurosci 10. 10(suppl 1)

Crook SM, Jung R, Venugopal S, Kurian M. (2009). Role of inhibition in the suppression of alpha motoneuron hyper-excitability following chronic incomplete spinal cord injury BMC Neurosci 10. 10(suppl 1)

Cullheim S, Kellerth JO. (1981). Two kinds of recurrent inhibition of cat spinal alpha-motoneurones as differentiated pharmacologically. The Journal of physiology. 312 [PubMed]

Dourado M, Sargent PB. (2002). Properties of nicotinic receptors underlying Renshaw cell excitation by alpha-motor neurons in neonatal rat spinal cord. Journal of neurophysiology. 87 [PubMed]

Elbasiouny SM, Bennett DJ, Mushahwar VK. (2006). Simulation of Ca2+ persistent inward currents in spinal motoneurones: mode of activation and integration of synaptic inputs. The Journal of physiology. 570 [PubMed]

Ermentrout GB. (2002). Simulating, Analyzing, and Animating Dynamical System: A Guide to XPPAUT for Researchers and Students Society for Industrial and Applied Mathematics (SIAM).

Ermentrout GB, Terman DH. (2010). Mathematical Foundations of Neuroscience Interdisciplinary Applied Mathematics. 35

Fyffe RE. (1991). Spatial distribution of recurrent inhibitory synapses on spinal motoneurons in the cat. Journal of neurophysiology. 65 [PubMed]

Gazula VR, Roberts M, Luzzio C, Jawad AF, Kalb RG. (2004). Effects of limb exercise after spinal cord injury on motor neuron dendrite structure. The Journal of comparative neurology. 476 [PubMed]

Gorassini MA, Knash ME, Harvey PJ, Bennett DJ, Yang JF. (2004). Role of motoneurons in the generation of muscle spasms after spinal cord injury. Brain : a journal of neurology. 127 [PubMed]

Gracies JM, Nance P, Elovic E, McGuire J, Simpson DM. (1997). Traditional pharmacological treatments for spasticity. Part II: General and regional treatments. Muscle & nerve. Supplement. 6 [PubMed]

Granit R, Haase J, Rutledge LT. (1960). Recurrent inhibition in relation to frequency of firing and limitation of discharge rate of extensor motoneurones. The Journal of physiology. 154 [PubMed]

Hamm TM, Crook SM, Jung R, Venugopal S. (2009). A computational study of the interaction between persistent inward currents and recurrent inhibition of alpha motoneurons before and after spinal cord injury (Abstract) Soc Neurosci Abstr 657.10.

Hamm TM, Crook SM, Jung R, Venugopal S. (2009). A computational study of the interaction between persistent inward currents and recurrent inhibition of alpha motoneurons before and after spinal cord injury (Abstract) Soc Neurosci Abstr 657.10.

Hamm TM, Jung R, Venugopal S. (2010). Role of low and high-voltage activated Ca2 dependent K currents in the control of alpha-motoneuron discharge and its implication in hyperreflexia BMC Neurosci 11. 11(Suppl 1)

Harvey PJ, Li X, Li Y, Bennett DJ. (2006). 5-HT2 receptor activation facilitates a persistent sodium current and repetitive firing in spinal motoneurons of rats with and without chronic spinal cord injury. Journal of neurophysiology. 96 [PubMed]

Harvey PJ, Li X, Li Y, Bennett DJ. (2006). Endogenous monoamine receptor activation is essential for enabling persistent sodium currents and repetitive firing in rat spinal motoneurons. Journal of neurophysiology. 96 [PubMed]

Heckman CJ. (1994). Alterations in synaptic input to motoneurons during partial spinal cord injury. Medicine and science in sports and exercise. 26 [PubMed]

Hounsgaard J, Hultborn H, Jespersen B, Kiehn O. (1988). Bistability of alpha-motoneurones in the decerebrate cat and in the acute spinal cat after intravenous 5-hydroxytryptophan. The Journal of physiology. 405 [PubMed]

Hultborn H, Denton ME, Wienecke J, Nielsen JB. (2003). Variable amplification of synaptic input to cat spinal motoneurones by dendritic persistent inward current. The Journal of physiology. 552 [PubMed]

Jean-Xavier C, Mentis GZ, O'Donovan MJ, Cattaert D, Vinay L. (2007). Dual personality of GABA/glycine-mediated depolarizations in immature spinal cord. Proceedings of the National Academy of Sciences of the United States of America. 104 [PubMed]

Jonas P, Bischofberger J, Sandkühler J. (1998). Corelease of two fast neurotransmitters at a central synapse. Science (New York, N.Y.). 281 [PubMed]

Kakinohana O et al. (2006). Development of GABA-sensitive spasticity and rigidity in rats after transient spinal cord ischemia: a qualitative and quantitative electrophysiological and histopathological study. Neuroscience. 141 [PubMed]

Katz R. (1999). Presynaptic inhibition in humans: a comparison between normal and spastic patients. Journal of physiology, Paris. 93 [PubMed]

Katz R, Pierrot-Deseilligny E. (1999). Recurrent inhibition in humans. Progress in neurobiology. 57 [PubMed]

Kiehn O, Kjaerulff O, Tresch MC, Harris-Warrick RM. (2000). Contributions of intrinsic motor neuron properties to the production of rhythmic motor output in the mammalian spinal cord. Brain research bulletin. 53 [PubMed]

Kitzman P. (2005). Alteration in axial motoneuronal morphology in the spinal cord injured spastic rat. Experimental neurology. 192 [PubMed]

Kjaerulff O, Kiehn O. (2001). 5-HT modulation of multiple inward rectifiers in motoneurons in intact preparations of the neonatal rat spinal cord. Journal of neurophysiology. 85 [PubMed]

Knopp A, Frahm C, Fidzinski P, Witte OW, Behr J. (2008). Loss of GABAergic neurons in the subiculum and its functional implications in temporal lobe epilepsy. Brain : a journal of neurology. 131 [PubMed]

Kurian M, Crook SM, Jung R. (2011). Motoneuron model of self-sustained firing after spinal cord injury. Journal of computational neuroscience. 31 [PubMed]

Lee RH, Heckman CJ. (1998). Bistability in spinal motoneurons in vivo: systematic variations in persistent inward currents. Journal of neurophysiology. 80 [PubMed]

Lee RH, Heckman CJ. (2000). Adjustable amplification of synaptic input in the dendrites of spinal motoneurons in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. 20 [PubMed]

Li X, Bennett DJ. (2007). Apamin-sensitive calcium-activated potassium currents (SK) are activated by persistent calcium currents in rat motoneurons. Journal of neurophysiology. 97 [PubMed]

Li X, Murray K, Harvey PJ, Ballou EW, Bennett DJ. (2007). Serotonin facilitates a persistent calcium current in motoneurons of rats with and without chronic spinal cord injury. Journal of neurophysiology. 97 [PubMed]

Li Y, Bennett DJ. (2003). Persistent sodium and calcium currents cause plateau potentials in motoneurons of chronic spinal rats. Journal of neurophysiology. 90 [PubMed]

Li Y, Gorassini MA, Bennett DJ. (2004). Role of persistent sodium and calcium currents in motoneuron firing and spasticity in chronic spinal rats. Journal of neurophysiology. 91 [PubMed]

Li Y, Harvey PJ, Li X, Bennett DJ. (2004). Spastic long-lasting reflexes of the chronic spinal rat studied in vitro. Journal of neurophysiology. 91 [PubMed]

Lindsay AD, Binder MD. (1991). Distribution of effective synaptic currents underlying recurrent inhibition in cat triceps surae motoneurons. Journal of neurophysiology. 65 [PubMed]

Maltenfort MG, McCurdy ML, Phillips CA, Turkin VV, Hamm TM. (2004). Location and magnitude of conductance changes produced by Renshaw recurrent inhibition in spinal motoneurons. Journal of neurophysiology. 92 [PubMed]

Mazzocchio R, Rossi A. (1997). Involvement of spinal recurrent inhibition in spasticity. Further insight into the regulation of Renshaw cell activity. Brain : a journal of neurology. 120 ( Pt 6) [PubMed]

McCurdy ML, Hamm TM. (1994). Topography of recurrent inhibitory postsynaptic potentials between individual motoneurons in the cat. Journal of neurophysiology. 72 [PubMed]

Murray KC et al. (2010). Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors. Nature medicine. 16 [PubMed]

Nielsen JB, Crone C, Hultborn H. (2007). The spinal pathophysiology of spasticity--from a basic science point of view. Acta physiologica (Oxford, England). 189 [PubMed]

Norton JA, Bennett DJ, Knash ME, Murray KC, Gorassini MA. (2008). Changes in sensory-evoked synaptic activation of motoneurons after spinal cord injury in man. Brain : a journal of neurology. 131 [PubMed]

Powers RK. (1993). A variable-threshold motoneuron model that incorporates time- and voltage-dependent potassium and calcium conductances. Journal of neurophysiology. 70 [PubMed]

Prather JF, Powers RK, Cope TC. (2001). Amplification and linear summation of synaptic effects on motoneuron firing rate. Journal of neurophysiology. 85 [PubMed]

Robinson GA, Goldberger ME. (1986). The development and recovery of motor function in spinal cats. II. Pharmacological enhancement of recovery. Experimental brain research. 62 [PubMed]

Ross HG, Cleveland S, Haase J. (1976). Quantitative relation between discharge frequencies of a Renshaw cell and an intracellularly depolarized motoneuron. Neuroscience letters. 3 [PubMed]

Russier M, Kopysova IL, Ankri N, Ferrand N, Debanne D. (2002). GABA and glycine co-release optimizes functional inhibition in rat brainstem motoneurons in vitro. The Journal of physiology. 541 [PubMed]

Rybak IA, Shevtsova NA, Ptak K, McCrimmon DR. (2004). Intrinsic bursting activity in the pre-Bötzinger complex: role of persistent sodium and potassium currents. Biological cybernetics. 90 [PubMed]

Sadlaoud K et al. (2010). Differential plasticity of the GABAergic and glycinergic synaptic transmission to rat lumbar motoneurons after spinal cord injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30 [PubMed]

Schneider SP, Fyffe RE. (1992). Involvement of GABA and glycine in recurrent inhibition of spinal motoneurons. Journal of neurophysiology. 68 [PubMed]

Schwindt P, Crill W. (1984). In Membrane properties of cat spinal motoneurons Handbook Of The Spinal Cord. 2-3

Shapiro S. (1997). Neurotransmission by neurons that use serotonin, noradrenaline, glutamate, glycine, and gamma-aminobutyric acid in the normal and injured spinal cord. Neurosurgery. 40 [PubMed]

Shefner JM, Berman SA, Sarkarati M, Young RR. (1992). Recurrent inhibition is increased in patients with spinal cord injury. Neurology. 42 [PubMed]

Turkin VV, O'Neill D, Jung R, Iarkov A, Hamm TM. (2010). Characteristics and organization of discharge properties in rat hindlimb motoneurons. Journal of neurophysiology. 104 [PubMed]

Van Keulen L. (1981). Autogenetic recurrent inhibition of individual spinal motoneurones of the cat. Neuroscience letters. 21 [PubMed]

Venugopal S, Travers JB, Terman DH. (2007). A computational model for motor pattern switching between taste-induced ingestion and rejection oromotor behaviors. Journal of computational neuroscience. 22 [PubMed]

Windhorst U, Hamm TM, Stuart DG, Sasaki S, Yuan CS. (1987). The measurement of single motor-axon recurrent inhibitory post-synaptic potentials in the cat. J Physiol. 388

Young RR. (1994). Spasticity: a review Neurology. 44

Zhong H et al. (2009). Changes in GABAA receptor subunit gamma 2 in extensor and flexor motoneurons and astrocytes after spinal cord transection and motor training Brain Res. 1273

References and models that cite this paper
This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.