These scripts were used to model a patch of layer 2/3 primary auditory cortex, making use of the the improvements to PGENESIS by Crone, et al. (2019). This single layer model contains a 48 x 48 grid of pyramidal cells (PCs) and a 24 x 24 grid of basket cells (BCs). The reduced PC models have 17 compartments with dimensions and passive properties that were fit to human cortical PC reconstructions. This parallel version of the simulation was used by Beeman, et al. (2019) to understand the effects of inhibition of PCs by BCs on auditory evoked potentials.
Model Type: Realistic Network
Region(s) or Organism(s): Auditory cortex
Cell Type(s): Neocortex L2/3 pyramidal GLU cell; Neocortex fast spiking (FS) interneuron
Simulation Environment: PGENESIS; GENESIS
Implementer(s): Beeman, Dave
References:
Beeman D, Yu A, Crone J. (2019). Studying evoked potentials in large cortical networks with PGENESIS 2.4 BMC Neuroscience. 20 Suppl 1
Crone JC et al. (2019). Enabling Large-Scale Simulations With the GENESIS Neuronal Simulator Frontiers in Neuroinformatics. 13