Our model consists of three interconnected populations of single or double compartment Hodgkin-Huxley neurons: a feedforward network of FSIs, and two networks of SPNs (the D1 receptor-expressing "direct pathway" subnetwork and the D2 receptor-expressing "indirect pathway" subnetwork).
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Striatum
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Neostriatum fast spiking interneuron
Currents: I Potassium; I M
Receptors: Dopaminergic Receptor
Model Concept(s): Oscillations; Beta oscillations; Gamma oscillations; Theta oscillations
Simulation Environment: DynaSim
Implementer(s): Chartove, Julia A K [chartove at bu dot edu]
References:
Chartove JA, McCarthy MM, Pittman-Polletta BR, Kopell NJ. (2020). A biophysical model of striatal microcircuits suggests gamma and beta oscillations interleaved at delta/theta frequencies mediate periodicity in motor control PLOS Computational Biology. 16