Striatal FSI and SPN oscillation model (Chartove et al. 2020)

Our model consists of three interconnected populations of single or double compartment Hodgkin-Huxley neurons: a feedforward network of FSIs, and two networks of SPNs (the D1 receptor-expressing "direct pathway" subnetwork and the D2 receptor-expressing "indirect pathway" subnetwork).

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Striatum

Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Neostriatum fast spiking interneuron

Currents: I Potassium; I M

Receptors: Dopaminergic Receptor

Transmitters: Dopamine; Gaba

Model Concept(s): Oscillations; Beta oscillations; Gamma oscillations; Theta oscillations

Simulation Environment: DynaSim

Implementer(s): Chartove, Julia A K [chartove at bu dot edu]


Chartove JA, McCarthy MM, Pittman-Polletta BR, Kopell NJ. (2020). A biophysical model of striatal microcircuits suggests gamma and beta oscillations interleaved at delta/theta frequencies mediate periodicity in motor control PLOS Computational Biology. 16

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