"During wakefulness, neocortical neurons are subjected to an intense synaptic bombardment. To assess the consequences of this background activity for the integrative properties of pyramidal neurons, we constrained biophysical models with in vivo intracellular data obtained in anesthetized cats during periods of intense network activity similar to that observed in the waking state. In pyramidal cells of the parietal cortex (area 5–7), synaptic activity was responsible for an approximately fivefold decrease in input resistance (Rin), a more depolarized membrane potential (Vm), and a marked increase in the amplitude of Vm fluctuations, as determined by comparing the same cells before and after microperfusion of tetrodotoxin (TTX). ..."
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Neocortex
Model Concept(s): Synaptic Integration
Simulation Environment: NEURON
Implementer(s): Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr]