Drosophila lateral ventral clock neuron (LNV) model (Smith et al 2019)


Smith P, Buhl E, Tsaneva-Atanasova K, Hodge JJL. (2019). Shaw and Shal voltage-gated potassium channels mediate circadian changes in Drosophila clock neuron excitability. The Journal of physiology. 597 [PubMed]

See more from authors: Smith P · Buhl E · Tsaneva-Atanasova K · Hodge JJL

References and models cited by this paper

Akemann W, Knöpfel T. (2006). Interaction of Kv3 potassium channels and resurgent sodium current influences the rate of spontaneous firing of Purkinje neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Allada R, Chung BY. (2010). Circadian organization of behavior and physiology in Drosophila. Annual review of physiology. 72 [PubMed]

Allen CN, Nitabach MN, Colwell CS. (2017). Membrane Currents, Gene Expression, and Circadian Clocks. Cold Spring Harbor perspectives in biology. 9 [PubMed]

Amarillo Y et al. (2008). Ternary Kv4.2 channels recapitulate voltage-dependent inactivation kinetics of A-type K+ channels in cerebellar granule neurons. The Journal of physiology. 586 [PubMed]

Belle MD, Diekman CO, Forger DB, Piggins HD. (2009). Daily electrical silencing in the mammalian circadian clock. Science (New York, N.Y.). 326 [PubMed]

Belle MDC, Allen CN. (2018). The circadian clock: A tale of genetic-electrical interplay and synaptic integration. Current opinion in physiology. 5 [PubMed]

Buhl E et al. (2016). Quasimodo mediates daily and acute light effects on Drosophila clock neuron excitability. Proceedings of the National Academy of Sciences of the United States of America. 113 [PubMed]

Bushey D, Huber R, Tononi G, Cirelli C. (2007). Drosophila Hyperkinetic mutants have reduced sleep and impaired memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27 [PubMed]

Cao G, Nitabach MN. (2008). Circadian control of membrane excitability in Drosophila melanogaster lateral ventral clock neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Chen C et al. (2015). Drosophila Ionotropic Receptor 25a mediates circadian clock resetting by temperature. Nature. 527 [PubMed]

Choi C et al. (2012). Autoreceptor control of peptide/neurotransmitter corelease from PDF neurons determines allocation of circadian activity in drosophila. Cell reports. 2 [PubMed]

Cirelli C et al. (2005). Reduced sleep in Drosophila Shaker mutants. Nature. 434 [PubMed]

Claridge-Chang A et al. (2001). Circadian regulation of gene expression systems in the Drosophila head. Neuron. 32 [PubMed]

Clark TG, Bradburn MJ, Love SB, Altman DG. (2003). Survival analysis part I: basic concepts and first analyses. British journal of cancer. 89 [PubMed]

Coetzee WA et al. (1999). Molecular diversity of K+ channels. Annals of the New York Academy of Sciences. 868 [PubMed]

Colwell CS. (2011). Linking neural activity and molecular oscillations in the SCN. Nature reviews. Neuroscience. 12 [PubMed]

Depetris-Chauvin A et al. (2011). Adult-specific electrical silencing of pacemaker neurons uncouples molecular clock from circadian outputs. Current biology : CB. 21 [PubMed]

Diekman CO et al. (2013). Causes and consequences of hyperexcitation in central clock neurons. PLoS computational biology. 9 [PubMed]

Emery P. (2012). Circadian rhythms: An electric jolt to the clock. Current biology : CB. 22 [PubMed]

Feng G et al. (2018). Control of Sleep Onset by Shal/Kv4 Channels in Drosophila Circadian Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 38 [PubMed]

Flourakis M et al. (2015). A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability. Cell. 162 [PubMed]

Fogle KJ et al. (2015). CRYPTOCHROME-mediated phototransduction by modulation of the potassium ion channel ß-subunit redox sensor. Proceedings of the National Academy of Sciences of the United States of America. 112 [PubMed]

Gasque G, Labarca P, Reynaud E, Darszon A. (2005). Shal and shaker differential contribution to the K+ currents in the Drosophila mushroom body neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25 [PubMed]

Goaillard JM, Marder E. (2006). Dynamic clamp analyses of cardiac, endocrine, and neural function. Physiology (Bethesda, Md.). 21 [PubMed]

Granados-Fuentes D, Hermanstyne TO, Carrasquillo Y, Nerbonne JM, Herzog ED. (2015). IA Channels Encoded by Kv1.4 and Kv4.2 Regulate Circadian Period of PER2 Expression in the Suprachiasmatic Nucleus. Journal of biological rhythms. 30 [PubMed]

Granados-Fuentes D, Norris AJ, Carrasquillo Y, Nerbonne JM, Herzog ED. (2012). I(A) channels encoded by Kv1.4 and Kv4.2 regulate neuronal firing in the suprachiasmatic nucleus and circadian rhythms in locomotor activity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32 [PubMed]

Grissmer S et al. (1994). Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines. Molecular pharmacology. 45 [PubMed]

Hablitz LM, Molzof HE, Paul JR, Johnson RL, Gamble KL. (2014). Suprachiasmatic nucleus function and circadian entrainment are modulated by G protein-coupled inwardly rectifying (GIRK) channels. The Journal of physiology. 592 [PubMed]

Helfrich-Förster C, Stengl M, Homberg U. (1998). Organization of the circadian system in insects. Chronobiology international. 15 [PubMed]

Helfrich-Förster C et al. (2007). The lateral and dorsal neurons of Drosophila melanogaster: new insights about their morphology and function. Cold Spring Harbor symposia on quantitative biology. 72 [PubMed]

Hermanstyne TO, Granados-Fuentes D, Mellor RL, Herzog ED, Nerbonne JM. (2017). Acute Knockdown of Kv4.1 Regulates Repetitive Firing Rates and Clock Gene Expression in the Suprachiasmatic Nucleus and Daily Rhythms in Locomotor Behavior. eNeuro. 4 [PubMed]

Herrington J et al. (2006). Blockers of the delayed-rectifier potassium current in pancreatic beta-cells enhance glucose-dependent insulin secretion. Diabetes. 55 [PubMed]

Hodge JJ, Choi JC, O'Kane CJ, Griffith LC. (2005). Shaw potassium channel genes in Drosophila. Journal of neurobiology. 63 [PubMed]

Hodge JJ, Stanewsky R. (2008). Function of the Shaw potassium channel within the Drosophila circadian clock. PloS one. 3 [PubMed]

Hodgkin AL, Huxley AF. (1990). A quantitative description of membrane current and its application to conduction and excitation in nerve. 1952. Bulletin of mathematical biology. 52 [PubMed]

Ingleby L, Maloney R, Jepson J, Horn R, Reenan R. (2009). Regulated RNA editing and functional epistasis in Shaker potassium channels. The Journal of general physiology. 133 [PubMed]

Irani SR et al. (2010). Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotonia. Brain : a journal of neurology. 133 [PubMed]

Itri JN, Michel S, Vansteensel MJ, Meijer JH, Colwell CS. (2005). Fast delayed rectifier potassium current is required for circadian neural activity. Nature neuroscience. 8 [PubMed]

Itri JN et al. (2010). Circadian regulation of a-type potassium currents in the suprachiasmatic nucleus. Journal of neurophysiology. 103 [PubMed]

Jan LY, Jan YN. (2012). Voltage-gated potassium channels and the diversity of electrical signalling. The Journal of physiology. 590 [PubMed]

Joho RH, Marks GA, Espinosa F. (2006). Kv3 potassium channels control the duration of different arousal states by distinct stochastic and clock-like mechanisms. The European journal of neuroscience. 23 [PubMed]

Julienne H, Buhl E, Leslie DS, Hodge JJL. (2017). Drosophila PINK1 and parkin loss-of-function mutants display a range of non-motor Parkinson's disease phenotypes. Neurobiology of disease. 104 [PubMed]

Kempf A, Song SM, Talbot CB, Miesenböck G. (2019). A potassium channel ß-subunit couples mitochondrial electron transport to sleep. Nature. 568 [PubMed]

Kent J, Meredith AL. (2008). BK channels regulate spontaneous action potential rhythmicity in the suprachiasmatic nucleus. PloS one. 3 [PubMed]

Ko GY, Shi L, Ko ML. (2009). Circadian regulation of ion channels and their functions. Journal of neurochemistry. 110 [PubMed]

Kudo T, Loh DH, Kuljis D, Constance C, Colwell CS. (2011). Fast delayed rectifier potassium current: critical for input and output of the circadian system. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31 [PubMed]

Kudo T et al. (2013). Vasoactive intestinal peptide produces long-lasting changes in neural activity in the suprachiasmatic nucleus. Journal of neurophysiology. 110 [PubMed]

Kula-Eversole E et al. (2010). Surprising gene expression patterns within and between PDF-containing circadian neurons in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. 107 [PubMed]

Kulik Y, Jones R, Moughamian AJ, Whippen J, Davis GW. (2019). Dual separable feedback systems govern firing rate homeostasis. eLife. 8 [PubMed]

Levine JD, Funes P, Dowse HB, Hall JC. (2002). Signal analysis of behavioral and molecular cycles. BMC neuroscience. 3 [PubMed]

Liss B et al. (2001). Tuning pacemaker frequency of individual dopaminergic neurons by Kv4.3L and KChip3.1 transcription. The EMBO journal. 20 [PubMed]

Mauvoisin D et al. (2014). Circadian clock-dependent and -independent rhythmic proteomes implement distinct diurnal functions in mouse liver. Proceedings of the National Academy of Sciences of the United States of America. 111 [PubMed]

McDonald MJ, Rosbash M. (2001). Microarray analysis and organization of circadian gene expression in Drosophila. Cell. 107 [PubMed]

McNally BA, Plante AE, Meredith AL. (2020). Diurnal properties of voltage-gated Ca2+ currents in suprachiasmatic nucleus and roles in action potential firing. The Journal of physiology. 598 [PubMed]

Meijer JH, Michel S. (2015). Neurophysiological analysis of the suprachiasmatic nucleus: a challenge at multiple levels. Methods in enzymology. 552 [PubMed]

Meredith AL et al. (2006). BK calcium-activated potassium channels regulate circadian behavioral rhythms and pacemaker output. Nature neuroscience. 9 [PubMed]

Mizrak D et al. (2012). Electrical activity can impose time of day on the circadian transcriptome of pacemaker neurons. Current biology : CB. 22 [PubMed]

Nakahata Y et al. (2008). A direct repeat of E-box-like elements is required for cell-autonomous circadian rhythm of clock genes. BMC molecular biology. 9 [PubMed]

Nitabach MN, Blau J, Holmes TC. (2002). Electrical silencing of Drosophila pacemaker neurons stops the free-running circadian clock. Cell. 109 [PubMed]

Nitabach MN, Holmes TC, Blau J. (2005). Membranes, ions, and clocks: testing the Njus-Sulzman-Hastings model of the circadian oscillator. Methods in enzymology. 393 [PubMed]

Panda S, Hogenesch JB, Kay SA. (2002). Circadian rhythms from flies to human. Nature. 417 [PubMed]

Parisky KM et al. (2008). PDF cells are a GABA-responsive wake-promoting component of the Drosophila sleep circuit. Neuron. 60 [PubMed]

Park JH, Hall JC. (1998). Isolation and chronobiological analysis of a neuropeptide pigment-dispersing factor gene in Drosophila melanogaster. Journal of biological rhythms. 13 [PubMed]

Park JH et al. (2000). Differential regulation of circadian pacemaker output by separate clock genes in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. 97 [PubMed]

Pennartz CM, de Jeu MT, Bos NP, Schaap J, Geurtsen AM. (2002). Diurnal modulation of pacemaker potentials and calcium current in the mammalian circadian clock. Nature. 416 [PubMed]

Ping Y et al. (2011). Shal/K(v)4 channels are required for maintaining excitability during repetitive firing and normal locomotion in Drosophila. PloS one. 6 [PubMed]

Prinz AA, Abbott LF, Marder E. (2004). The dynamic clamp comes of age. Trends in neurosciences. 27 [PubMed]

Robles MS, Cox J, Mann M. (2014). In-vivo quantitative proteomics reveals a key contribution of post-transcriptional mechanisms to the circadian regulation of liver metabolism. PLoS genetics. 10 [PubMed]

Ruben M, Drapeau MD, Mizrak D, Blau J. (2012). A mechanism for circadian control of pacemaker neuron excitability. Journal of biological rhythms. 27 [PubMed]

Rudy B, McBain CJ. (2001). Kv3 channels: voltage-gated K+ channels designed for high-frequency repetitive firing. Trends in neurosciences. 24 [PubMed]

Ryan MY, Maloney R, Reenan R, Horn R. (2008). Characterization of five RNA editing sites in Shab potassium channels. Channels (Austin, Tex.). 2 [PubMed]

Schubert FK, Hagedorn N, Yoshii T, Helfrich-Förster C, Rieger D. (2018). Neuroanatomical details of the lateral neurons of Drosophila melanogaster support their functional role in the circadian system. The Journal of comparative neurology. 526 [PubMed]

Sheeba V et al. (2008). Large ventral lateral neurons modulate arousal and sleep in Drosophila. Current biology : CB. 18 [PubMed]

Sheeba V, Gu H, Sharma VK, O'Dowd DK, Holmes TC. (2008). Circadian- and light-dependent regulation of resting membrane potential and spontaneous action potential firing of Drosophila circadian pacemaker neurons. Journal of neurophysiology. 99 [PubMed]

Shelley C, Whitt JP, Montgomery JR, Meredith AL. (2013). Phosphorylation of a constitutive serine inhibits BK channel variants containing the alternate exon "SRKR". The Journal of general physiology. 142 [PubMed]

Sim CK, Forger DB. (2007). Modeling the electrophysiology of suprachiasmatic nucleus neurons. Journal of biological rhythms. 22 [PubMed]

Smith P et al. (2018). A Drosophila Model of Essential Tremor. Scientific reports. 8 [PubMed]

Taghert PH, Shafer OT. (2006). Mechanisms of clock output in the Drosophila circadian pacemaker system. Journal of biological rhythms. 21 [PubMed]

Tanoue S, Krishnan P, Krishnan B, Dryer SE, Hardin PE. (2004). Circadian clocks in antennal neurons are necessary and sufficient for olfaction rhythms in Drosophila. Current biology : CB. 14 [PubMed]

Torczon V, Lewis R, Kolda T. (2003). Optimization by direct search: new perspectives on some classical and modern methods. SIAM Rev. 45(3)

Tsunoda S, Salkoff L. (1995). Genetic analysis of Drosophila neurons: Shal, Shaw, and Shab encode most embryonic potassium currents. The Journal of neuroscience : the official journal of the Society for Neuroscience. 15 [PubMed]

Wang LY, Gan L, Forsythe ID, Kaczmarek LK. (1998). Contribution of the Kv3.1 potassium channel to high-frequency firing in mouse auditory neurones. The Journal of physiology. 509 ( Pt 1) [PubMed]

Wang Q, Abruzzi KC, Rosbash M, Rio DC. (2018). Striking circadian neuron diversity and cycling of Drosophila alternative splicing. eLife. 7 [PubMed]

Whitt JP, Montgomery JR, Meredith AL. (2016). BK channel inactivation gates daytime excitability in the circadian clock. Nature communications. 7 [PubMed]

Wu Y, Cao G, Nitabach MN. (2008). Electrical silencing of PDF neurons advances the phase of non-PDF clock neurons in Drosophila. Journal of biological rhythms. 23 [PubMed]

Yang Z, Sehgal A. (2001). Role of molecular oscillations in generating behavioral rhythms in Drosophila. Neuron. 29 [PubMed]

Yeung SY, Thompson D, Wang Z, Fedida D, Robertson B. (2005). Modulation of Kv3 subfamily potassium currents by the sea anemone toxin BDS: significance for CNS and biophysical studies. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25 [PubMed]

Zwarts L, Vulsteke V, Buhl E, Hodge JJL, Callaerts P. (2017). SlgA, encoded by the homolog of the human schizophrenia-associated gene PRODH, acts in clock neurons to regulate Drosophila aggression. Disease models & mechanisms. 10 [PubMed]

References and models that cite this paper
This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.