The microcircuits of striatum in silico (Hjorth et al 2020)

"Our aim is to reconstruct a full-scale mouse striatal cellular level model to provide a framework to integrate and interpret striatal data. We represent the main striatal neuronal subtypes, the two types of projection neurons (dSPNs and iSPNs) giving rise to the direct and indirect pathways, the fast-spiking interneurons, the low threshold spiking interneurons, and the cholinergic interneurons as detailed compartmental models, with properties close to their biological counterparts. Both intrastriatal and afferent synaptic inputs (cortex, thalamus, dopamine system) are optimized against existing data, including short-term plasticity. This model platform will be used to generate new hypotheses on striatal function or network dynamic phenomena."

Model Type: Realistic Network

Region(s) or Organism(s): Striatum; Basal ganglia

Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Neostriatum interneuron ACh cell; Neostriatum interneuron gaba/parvalbumin GABA cell; Neostriatum interneuron SOM/NOS GABA cell; Neostriatum spiny neuron; Neostriatum fast spiking interneuron

Currents: I Na,t; I K; I A; I A, slow; I T low threshold; I K,Ca; I N; I Q; I R; Kir

Genes: Cav2.1 CACNA1A; Cav2.2 CACNA1B; Cav3.1 CACNA1G; Cav3.2 CACNA1H

Model Concept(s): Methods

Simulation Environment: NEURON (web link to model); Snudda (web link to model)

Implementer(s): Hjorth, Johannes [hjorth at]


Hjorth JJJ et al. (2020). The microcircuits of striatum in silico. Proceedings of the National Academy of Sciences of the United States of America. 117 [PubMed]

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